Detailed information of TA system TA104368

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3509121..3510342
• Replicon: chromosome
• Accession: NZ_CP028917
• Organism: Pseudomonas aeruginosa strain JB2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0H2Z8V4
• Locus tag: C5B40_RS16945
• Protein ID: WP_003110488.1
• Coordinates: 3509121..3509699 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: C5B40_RS16950
• Protein ID: WP_003132728.1
• Coordinates: 3509788..3510342 (-)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C5B40_RS16930	3504396..3505673	+	1278	WP_003102743.1	TolC family protein	-
C5B40_RS16935	3505663..3507834	+	2172	WP_003132730.1	type I secretion system permease/ATPase	-
C5B40_RS16940	3507824..3509011	+	1188	WP_003132729.1	HlyD family efflux transporter periplasmic adaptor subunit	-
C5B40_RS16945	3509121..3509699	-	579	WP_003110488.1	HD domain-containing protein	Toxin
C5B40_RS16950	3509788..3510342	-	555	WP_003132728.1	helix-turn-helix domain-containing protein	Antitoxin
C5B40_RS16955	3510502..3512697	-	2196	WP_024947749.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
C5B40_RS16960	3512702..3513163	-	462	WP_003088117.1	(2Fe-2S)-binding protein	-
C5B40_RS16965	3513494..3513817	+	324	WP_003102734.1	multidrug efflux SMR transporter	-
C5B40_RS16970	3513830..3514228	+	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
C5B40_RS16975	3514225..3514776	-	552	WP_003132721.1	XRE family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (7-188)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21913.75 Da
• Isoelectric Point: 5.3655

>T104368 WP_003110488.1 NZ_CP028917:c3509699-3509121 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T104368 NZ_CP028917:c3509699-3509121 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTTTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTTCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAAGCGGCGCACCCGGACAAGGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCATCTGGACAC
GCCGCTGCGCGATCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGACCGCCGAAGCCCTGGCAGTGAAAGCGC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGATCGCGCACCGCTGTTCAAGACCCTGCGCGAGTTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20470.63 Da
• Isoelectric Point: 8.1590

>AT104368 WP_003132728.1 NZ_CP028917:c3510342-3509788 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLESAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT104368 NZ_CP028917:c3510342-3509788 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCCTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAAGCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGCTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
ACCCCTCGGCGAACTGCTCGACCGTTCGCTCTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTACGCCTGGTGGAAACCCTCTGA

Structures

Toxin

• AlphaFold DB: A0A0H2Z8V4