Detailed information of TA system TA104360

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 452196..452986
• Replicon: chromosome
• Accession: NZ_CP028901
• Organism: Algicoccus marinus strain HZ20

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: DBV39_RS01965
• Protein ID: WP_108620122.1
• Coordinates: 452486..452986 (+)
• Length: 167 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: -
• Locus tag: DBV39_RS01960
• Protein ID: WP_108620121.1
• Coordinates: 452196..452489 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DBV39_RS01935	447729..448187	+	459	WP_108620117.1	cytochrome c	-
DBV39_RS01940	448470..449165	-	696	WP_108620118.1	cytochrome b/b6 domain-containing protein	-
DBV39_RS01950	449763..451124	+	1362	WP_159078733.1	site-specific integrase	-
DBV39_RS19365	451340..451492	-	153	WP_159078734.1	hypothetical protein	-
DBV39_RS01955	451538..452083	-	546	WP_108620120.1	transposase	-
DBV39_RS01960	452196..452489	+	294	WP_108620121.1	DUF1778 domain-containing protein	Antitoxin
DBV39_RS01965	452486..452986	+	501	WP_108620122.1	GNAT family N-acetyltransferase	Toxin
DBV39_RS01970	453182..453439	-	258	WP_108620123.1	Txe/YoeB family addiction module toxin	-
DBV39_RS01975	453414..453701	-	288	WP_108620124.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
DBV39_RS01980	453880..454419	+	540	Protein_376	transposase	-
DBV39_RS19670	454732..455031	-	300	WP_193853043.1	hypothetical protein	-
DBV39_RS19370	455108..455206	-	99	Protein_378	hypothetical protein	-
DBV39_RS01995	455311..455592	-	282	WP_108620126.1	hypothetical protein	-
DBV39_RS02000	455605..456111	-	507	WP_159078735.1	hypothetical protein	-
DBV39_RS02005	456354..457214	+	861	WP_108620128.1	DUF4338 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (40-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (1-96)

Sequences

Toxin

Protein

• Length: 167 a.a.
• Molecular weight: 18434.34 Da
• Isoelectric Point: 9.6786

>T104360 WP_108620122.1 NZ_CP028901:452486-452986 [Algicoccus marinus]
VTLRAPEPLDAQHRLEGFDCGKPALNDWLLRYARQAQGSGSAKTFVVAEDDGRVAGYFSLTVGQVDTLEAPERIRKGMGQ
YPLPVVILARLAVSIHDQGRGIGFGLLQNAIRRTMLIAEQAGIRAMLTHPIDEEAARFCTRFGFIASPLREPQLLLLLKD
ARRWVR

Nucleotide

• Length: 501 bp

>T104360 NZ_CP028901:452486-452986 [Algicoccus marinus]
GTGACGTTGCGCGCACCGGAGCCTCTGGACGCGCAACATCGGCTGGAGGGTTTTGATTGCGGCAAGCCTGCGCTCAATGA
CTGGTTGTTGCGCTACGCCCGCCAGGCCCAGGGCAGTGGCTCGGCCAAGACCTTTGTTGTTGCCGAGGACGATGGCCGCG
TGGCGGGCTACTTCAGCCTGACCGTGGGGCAAGTCGACACGCTGGAGGCGCCGGAGCGCATCCGCAAGGGGATGGGGCAG
TACCCTTTACCAGTGGTGATCTTGGCGAGACTGGCCGTATCCATTCACGATCAGGGGCGAGGCATCGGCTTTGGTCTGCT
ACAGAATGCCATTCGCCGCACGATGCTGATTGCCGAGCAGGCCGGCATCCGTGCCATGCTGACTCACCCCATCGATGAAG
AAGCAGCGAGGTTCTGCACCCGGTTCGGGTTCATCGCGTCACCGCTGCGCGAACCGCAATTGCTGCTGCTCTTGAAGGAC
GCCCGTCGCTGGGTCCGGTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10686.19 Da
• Isoelectric Point: 5.0771

>AT104360 WP_108620121.1 NZ_CP028901:452196-452489 [Algicoccus marinus]
MTAVASSSSARSARLGLRATPEQEVMLRRAAEVAHKSLTDFILDSACLAAEQTLLDQRLFMVSGSQYQALMDLLDRPEQA
NEGLRDLFACKAPWDTK

Nucleotide

• Length: 294 bp

>AT104360 NZ_CP028901:452196-452489 [Algicoccus marinus]
ATGACCGCTGTTGCATCGTCGTCTTCCGCCCGCTCTGCCCGGCTGGGGCTACGCGCCACCCCCGAACAGGAGGTGATGCT
GCGCCGCGCTGCCGAGGTGGCCCACAAGTCGTTGACTGACTTCATCCTCGACAGTGCGTGCCTGGCCGCCGAGCAGACCC
TGCTCGATCAACGATTGTTCATGGTTTCGGGCAGCCAGTACCAGGCCCTGATGGATCTGCTGGATCGCCCTGAACAGGCC
AATGAGGGTTTGCGTGACCTGTTTGCCTGCAAGGCGCCCTGGGACACGAAGTGA