Detailed information of TA system TA104353

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 1175948..1176458
• Replicon: chromosome
• Accession: NZ_CP028897
• Organism: Dongshaea marina strain DM2

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: DB847_RS05855
• Protein ID: WP_108649852.1
• Coordinates: 1175948..1176208 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: DB847_RS05860
• Protein ID: WP_108649853.1
• Coordinates: 1176201..1176458 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DB847_RS05815	1171240..1172112	+	873	WP_108649844.1	glucose-1-phosphate thymidylyltransferase RfbA	-
DB847_RS05820	1172120..1172665	+	546	WP_108649845.1	dTDP-4-dehydrorhamnose 3,5-epimerase	-
DB847_RS05825	1172688..1173473	+	786	WP_108649846.1	glycosyltransferase family 2 protein	-
DB847_RS05830	1173478..1173774	-	297	WP_108649847.1	YciI family protein	-
DB847_RS05835	1173833..1174492	-	660	WP_108649848.1	ribose-5-phosphate isomerase RpiA	-
DB847_RS05840	1174517..1174924	-	408	WP_108649849.1	HI0074 family nucleotidyltransferase substrate-binding subunit	-
DB847_RS05845	1174908..1175216	-	309	WP_108649850.1	nucleotidyltransferase domain-containing protein	-
DB847_RS05850	1175327..1175866	-	540	WP_108649851.1	septation protein A	-
DB847_RS05855	1175948..1176208	-	261	WP_108649852.1	Txe/YoeB family addiction module toxin	Toxin
DB847_RS05860	1176201..1176458	-	258	WP_108649853.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
DB847_RS05865	1176566..1176895	-	330	WP_159084420.1	helix-hairpin-helix domain-containing protein	-
DB847_RS05875	1177422..1178219	-	798	WP_108649856.1	alpha/beta hydrolase	-
DB847_RS05880	1178329..1178661	+	333	WP_108649857.1	helix-turn-helix transcriptional regulator	-
DB847_RS05885	1178738..1179157	+	420	WP_108649858.1	acyl-CoA thioesterase	-
DB847_RS05890	1179361..1180170	-	810	WP_108649859.1	tryptophan synthase subunit alpha	-
DB847_RS05895	1180170..1181360	-	1191	WP_108649860.1	tryptophan synthase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10348.81 Da
• Isoelectric Point: 8.9903

>T104353 WP_108649852.1 NZ_CP028897:c1176208-1175948 [Dongshaea marina]
MNRQLAWTDEAWNSYIYWQGQDRKTLKRINKLIDAAKRSPFEGIGKPEPLKENLSGCWSRRITDEHRLVYIVDDLYLTIL
SCRYHY

Nucleotide

• Length: 261 bp

>T104353 NZ_CP028897:c1176208-1175948 [Dongshaea marina]
ATGAATAGACAACTGGCATGGACTGATGAAGCCTGGAACTCATACATCTACTGGCAGGGTCAAGATAGAAAGACTCTCAA
GCGGATCAACAAACTCATAGATGCAGCCAAACGCAGTCCATTTGAGGGAATCGGAAAACCTGAGCCGCTTAAAGAAAACC
TGAGTGGCTGCTGGTCGCGGCGTATTACAGATGAGCATCGCCTGGTTTACATCGTTGATGATCTTTATCTCACCATCCTC
TCCTGCCGTTACCACTATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9497.65 Da
• Isoelectric Point: 4.7640

>AT104353 WP_108649853.1 NZ_CP028897:c1176458-1176201 [Dongshaea marina]
MRVVSYTDARGNLKQVLDNVVEDADYTVITRRNADDAVVMSLESFNSLMETVHLLKSPANASHLERSLAQYKSGQAKVKD
LLDDE

Nucleotide

• Length: 258 bp

>AT104353 NZ_CP028897:c1176458-1176201 [Dongshaea marina]
ATGCGGGTAGTCTCATATACAGATGCCAGAGGCAATCTCAAGCAGGTCTTAGACAATGTGGTCGAAGATGCTGATTACAC
AGTGATAACACGCCGTAATGCTGATGATGCCGTAGTTATGTCTCTTGAATCATTTAACAGCCTGATGGAAACTGTCCATC
TACTCAAGTCTCCAGCCAATGCTTCTCATTTAGAACGCTCACTGGCTCAGTACAAGTCAGGTCAGGCCAAAGTAAAAGAT
CTTCTCGACGATGAATAG