Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-Phd |
| Location | 457435..458013 | Replicon | chromosome |
| Accession | NZ_CP028893 | ||
| Organism | Vibrio cholerae strain Sa5Y | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | Sa5Y_RS16940 | Protein ID | WP_162298942.1 |
| Coordinates | 457435..457752 (-) | Length | 106 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | Q7DCR7 |
| Locus tag | Sa5Y_RS16945 | Protein ID | WP_000557292.1 |
| Coordinates | 457771..458013 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| Sa5Y_RS16875 | 453060..453194 | + | 135 | WP_019830500.1 | DUF645 family protein | - |
| Sa5Y_RS16885 | 453557..453781 | + | 225 | WP_094393000.1 | hypothetical protein | - |
| Sa5Y_RS16890 | 454069..454200 | + | 132 | WP_162298941.1 | DUF3709 domain-containing protein | - |
| Sa5Y_RS16895 | 454213..454287 | + | 75 | WP_108244119.1 | hypothetical protein | - |
| Sa5Y_RS16900 | 454708..454839 | + | 132 | WP_162298941.1 | DUF3709 domain-containing protein | - |
| Sa5Y_RS16905 | 454852..454926 | + | 75 | WP_108244120.1 | hypothetical protein | - |
| Sa5Y_RS16910 | 455195..455620 | + | 426 | WP_094393063.1 | GNAT family N-acetyltransferase | - |
| Sa5Y_RS16915 | 455758..456234 | + | 477 | Protein_512 | GNAT family N-acetyltransferase | - |
| Sa5Y_RS16925 | 456529..456655 | + | 127 | Protein_513 | DUF645 family protein | - |
| Sa5Y_RS16930 | 456671..456709 | + | 39 | WP_108244118.1 | hypothetical protein | - |
| Sa5Y_RS16935 | 457071..457242 | + | 172 | Protein_515 | DUF645 family protein | - |
| Sa5Y_RS16940 | 457435..457752 | - | 318 | WP_162298942.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| Sa5Y_RS16945 | 457771..458013 | - | 243 | WP_000557292.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| Sa5Y_RS16950 | 458241..458711 | - | 471 | WP_000784954.1 | RES family NAD+ phosphorylase | - |
| Sa5Y_RS16955 | 458711..459163 | - | 453 | WP_000024295.1 | DUF2384 domain-containing protein | - |
| Sa5Y_RS16960 | 459383..459919 | + | 537 | WP_094392990.1 | nucleotidyltransferase family protein | - |
| Sa5Y_RS16965 | 460063..460527 | + | 465 | WP_057552715.1 | GNAT family N-acetyltransferase | - |
| Sa5Y_RS16970 | 460820..461002 | + | 183 | WP_094392988.1 | DUF645 family protein | - |
| Sa5Y_RS16980 | 461218..461781 | + | 564 | WP_162298940.1 | hypothetical protein | - |
| Sa5Y_RS16985 | 461939..462391 | + | 453 | WP_094393102.1 | GNAT family N-acetyltransferase | - |
| Sa5Y_RS16990 | 462448..462843 | + | 396 | WP_162298943.1 | DUF4144 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 306104..472928 | 166824 | |
| - | inside | Integron | - | - | 307268..474111 | 166843 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12132.89 Da Isoelectric Point: 9.2626
>T104332 WP_162298942.1 NZ_CP028893:c457752-457435 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAD
FILIVAVLGQSQLPQKHLTQSRFVS
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAD
FILIVAVLGQSQLPQKHLTQSRFVS
Download Length: 318 bp
>T104332 NZ_CP028893:c457752-457435 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTAGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAGAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAGCTGCCCCAGAAACATCTCACACAATCACGTTTCGTTTCTTAG
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTAGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAGAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAGCTGCCCCAGAAACATCTCACACAATCACGTTTCGTTTCTTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 8961.25 Da Isoelectric Point: 5.6630
>AT104332 WP_000557292.1 NZ_CP028893:c458013-457771 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL
Download Length: 243 bp
>AT104332 NZ_CP028893:c458013-457771 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|