104331

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 452125..452653 Replicon chromosome
Accession NZ_CP028893
Organism Vibrio cholerae strain Sa5Y

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag Sa5Y_RS16865 Protein ID WP_000221352.1
Coordinates 452125..452415 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag Sa5Y_RS16870 Protein ID WP_000213183.1
Coordinates 452405..452653 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Sa5Y_RS16815 447410..447907 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
Sa5Y_RS16820 447904..448176 - 273 WP_001915058.1 DUF1778 domain-containing protein -
Sa5Y_RS16825 448422..448709 + 288 WP_094392995.1 SHOCT domain-containing protein -
Sa5Y_RS16830 448777..449010 + 234 WP_094392996.1 hypothetical protein -
Sa5Y_RS16835 449013..449129 + 117 WP_094392999.1 DUF3265 domain-containing protein -
Sa5Y_RS16840 449139..449654 + 516 WP_000090011.1 hypothetical protein -
Sa5Y_RS16845 449774..450262 + 489 WP_057561119.1 dual specificity protein phosphatase family protein -
Sa5Y_RS16850 450285..451244 - 960 WP_094393086.1 IS30 family transposase -
Sa5Y_RS16855 451489..451998 + 510 WP_094392997.1 GNAT family N-acetyltransferase -
Sa5Y_RS16865 452125..452415 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Sa5Y_RS16870 452405..452653 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
Sa5Y_RS16875 453060..453194 + 135 WP_019830500.1 DUF645 family protein -
Sa5Y_RS16885 453557..453781 + 225 WP_094393000.1 hypothetical protein -
Sa5Y_RS16890 454069..454200 + 132 WP_162298941.1 DUF3709 domain-containing protein -
Sa5Y_RS16895 454213..454287 + 75 WP_108244119.1 hypothetical protein -
Sa5Y_RS16900 454708..454839 + 132 WP_162298941.1 DUF3709 domain-containing protein -
Sa5Y_RS16905 454852..454926 + 75 WP_108244120.1 hypothetical protein -
Sa5Y_RS16910 455195..455620 + 426 WP_094393063.1 GNAT family N-acetyltransferase -
Sa5Y_RS16915 455758..456234 + 477 Protein_512 GNAT family N-acetyltransferase -
Sa5Y_RS16925 456529..456655 + 127 Protein_513 DUF645 family protein -
Sa5Y_RS16930 456671..456709 + 39 WP_108244118.1 hypothetical protein -
Sa5Y_RS16935 457071..457242 + 172 Protein_515 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 306104..472928 166824
- inside Integron - - 307268..474111 166843


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T104331 WP_000221352.1 NZ_CP028893:c452415-452125 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T104331 NZ_CP028893:c452415-452125 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCGGGCGCTGAGAATATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT104331 WP_000213183.1 NZ_CP028893:c452653-452405 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT104331 NZ_CP028893:c452653-452405 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGCGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References