Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 446011..446570 | Replicon | chromosome |
| Accession | NZ_CP028893 | ||
| Organism | Vibrio cholerae strain Sa5Y | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A0Q0N9E9 |
| Locus tag | Sa5Y_RS16795 | Protein ID | WP_000578475.1 |
| Coordinates | 446011..446289 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9L991 |
| Locus tag | Sa5Y_RS16800 | Protein ID | WP_000381183.1 |
| Coordinates | 446286..446570 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| Sa5Y_RS16745 | 441332..441727 | + | 396 | WP_000870847.1 | DUF3465 domain-containing protein | - |
| Sa5Y_RS16750 | 441902..443035 | + | 1134 | WP_128739198.1 | RelA/SpoT domain-containing protein | - |
| Sa5Y_RS16755 | 443331..443513 | + | 183 | WP_108244027.1 | DUF645 family protein | - |
| Sa5Y_RS16765 | 443729..444292 | + | 564 | WP_162298940.1 | hypothetical protein | - |
| Sa5Y_RS16770 | 444597..444779 | + | 183 | WP_094392988.1 | DUF645 family protein | - |
| Sa5Y_RS16780 | 445131..445313 | + | 183 | WP_108244031.1 | DUF645 family protein | - |
| Sa5Y_RS16790 | 445496..445858 | + | 363 | WP_175234023.1 | hypothetical protein | - |
| Sa5Y_RS16795 | 446011..446289 | - | 279 | WP_000578475.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| Sa5Y_RS16800 | 446286..446570 | - | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| Sa5Y_RS16810 | 446857..447135 | + | 279 | WP_033932156.1 | DUF3709 domain-containing protein | - |
| Sa5Y_RS16815 | 447410..447907 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
| Sa5Y_RS16820 | 447904..448176 | - | 273 | WP_001915058.1 | DUF1778 domain-containing protein | - |
| Sa5Y_RS16825 | 448422..448709 | + | 288 | WP_094392995.1 | SHOCT domain-containing protein | - |
| Sa5Y_RS16830 | 448777..449010 | + | 234 | WP_094392996.1 | hypothetical protein | - |
| Sa5Y_RS16835 | 449013..449129 | + | 117 | WP_094392999.1 | DUF3265 domain-containing protein | - |
| Sa5Y_RS16840 | 449139..449654 | + | 516 | WP_000090011.1 | hypothetical protein | - |
| Sa5Y_RS16845 | 449774..450262 | + | 489 | WP_057561119.1 | dual specificity protein phosphatase family protein | - |
| Sa5Y_RS16850 | 450285..451244 | - | 960 | WP_094393086.1 | IS30 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 306104..472928 | 166824 | |
| - | inside | Integron | - | - | 307268..474111 | 166843 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10824.53 Da Isoelectric Point: 4.6794
>T104329 WP_000578475.1 NZ_CP028893:c446289-446011 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDEVIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDEVIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
Download Length: 279 bp
>T104329 NZ_CP028893:c446289-446011 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCCGC
TGAAAAAACGGACGAGGTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATGGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATCGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCCGC
TGAAAAAACGGACGAGGTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATGGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATCGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10901.25 Da Isoelectric Point: 8.0775
>AT104329 WP_000381183.1 NZ_CP028893:c446570-446286 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
Download Length: 285 bp
>AT104329 NZ_CP028893:c446570-446286 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGTCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGTCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0Q0N9E9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067BL33 |