Detailed information of TA system TA104328

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-Phd
• Location: 438030..438577
• Replicon: chromosome
• Accession: NZ_CP028893
• Organism: Vibrio cholerae strain Sa5Y

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: Sa5Y_RS16720
• Protein ID: WP_095486992.1
• Coordinates: 438275..438577 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: Sa5Y_RS16715
• Protein ID: WP_055031549.1
• Coordinates: 438030..438287 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Sa5Y_RS16670	433364..433651	+	288	WP_162298939.1	type II toxin-antitoxin system RelE/ParE family toxin	-
Sa5Y_RS16675	433662..433979	+	318	WP_001232701.1	HigA family addiction module antidote protein	-
Sa5Y_RS16685	434479..434649	+	171	Protein_474	DUF645 family protein	-
Sa5Y_RS16690	434867..435997	+	1131	WP_094393023.1	DUF4238 domain-containing protein	-
Sa5Y_RS16695	436201..436590	+	390	WP_000491261.1	VOC family protein	-
Sa5Y_RS20240	436675..436794	+	120	WP_162843095.1	acetyltransferase	-
Sa5Y_RS16705	436778..437014	-	237	WP_000772130.1	RNA-binding protein	-
Sa5Y_RS16715	438030..438287	+	258	WP_055031549.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
Sa5Y_RS16720	438275..438577	+	303	WP_095486992.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Sa5Y_RS16725	438743..439459	+	717	WP_094393090.1	hypothetical protein	-
Sa5Y_RS16730	439482..440441	-	960	WP_094393086.1	IS30 family transposase	-
Sa5Y_RS16740	440766..441044	+	279	WP_033932156.1	DUF3709 domain-containing protein	-
Sa5Y_RS16745	441332..441727	+	396	WP_000870847.1	DUF3465 domain-containing protein	-
Sa5Y_RS16750	441902..443035	+	1134	WP_128739198.1	RelA/SpoT domain-containing protein	-
Sa5Y_RS16755	443331..443513	+	183	WP_108244027.1	DUF645 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	306104..472928	166824
	-	inside	Integron	-	-	307268..474111	166843

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11771.73 Da
• Isoelectric Point: 5.8807

>T104328 WP_095486992.1 NZ_CP028893:438275-438577 [Vibrio cholerae]
MAEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRIPPELEHLNYREVVVNPCRVFYKYYDAKV
RILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T104328 NZ_CP028893:438275-438577 [Vibrio cholerae]
ATGGCTGAAATAATTTGGACGGAGCCGGCTCTATCCGACCTAAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCAGCCAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTAGCCGATTTTCCAGAATCTGGACGTATCCCGC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAATCCGTGTCGTGTTTTCTACAAGTATTATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9619.14 Da
• Isoelectric Point: 7.3176

>AT104328 WP_055031549.1 NZ_CP028893:438030-438287 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDKM
SKWLK

Nucleotide

• Length: 258 bp

>AT104328 NZ_CP028893:438030-438287 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTAATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGTGGTGAGCGAGCTCTAGCGGATGGCAAAGTGGTCAGTCATCAAGATGCTAAGGACAAAATG
TCAAAATGGCTGAAATAA