104326

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 414219..414757 Replicon chromosome
Accession NZ_CP028893
Organism Vibrio cholerae strain Sa5Y

Toxin (Protein)


Gene name parE Uniprot ID A0A0N8UHD2
Locus tag Sa5Y_RS16410 Protein ID WP_000802131.1
Coordinates 414219..414518 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0Q0JMN6
Locus tag Sa5Y_RS16415 Protein ID WP_002044787.1
Coordinates 414515..414757 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Sa5Y_RS16345 409259..409771 + 513 WP_057552823.1 hypothetical protein -
Sa5Y_RS16350 409931..410290 + 360 WP_108244018.1 VOC family protein -
Sa5Y_RS16360 410578..410760 + 183 WP_001933122.1 DUF645 family protein -
Sa5Y_RS16365 410969..411526 + 558 WP_095488179.1 3'-5' exonuclease -
Sa5Y_RS16370 411523..411633 + 111 Protein_430 DUF3265 domain-containing protein -
Sa5Y_RS16375 411779..412270 + 492 WP_095457944.1 hypothetical protein -
Sa5Y_RS16390 412563..412745 + 183 WP_057556394.1 DUF645 family protein -
Sa5Y_RS16400 412924..413361 + 438 WP_108244019.1 hypothetical protein -
Sa5Y_RS16405 414086..414211 + 126 WP_095488177.1 DUF3265 domain-containing protein -
Sa5Y_RS16410 414219..414518 - 300 WP_000802131.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Sa5Y_RS16415 414515..414757 - 243 WP_002044787.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
Sa5Y_RS16420 414805..414936 + 132 WP_080483479.1 DUF3265 domain-containing protein -
Sa5Y_RS16425 414965..415462 + 498 WP_094392957.1 DUF2867 domain-containing protein -
Sa5Y_RS16440 415767..415937 + 171 WP_094392956.1 DUF645 family protein -
Sa5Y_RS16445 416153..416548 + 396 WP_094392955.1 cell envelope integrity protein TolA -
Sa5Y_RS16455 416831..417022 + 192 WP_094392953.1 DUF3709 domain-containing protein -
Sa5Y_RS20310 417253..417357 + 105 Protein_442 acetyltransferase -
Sa5Y_RS16460 417373..417726 + 354 WP_172626102.1 nuclear transport factor 2 family protein -
Sa5Y_RS16465 417872..418324 + 453 WP_000863106.1 GNAT family N-acetyltransferase -
Sa5Y_RS16470 418615..419028 + 414 WP_061036318.1 hypothetical protein -
Sa5Y_RS16480 419318..419500 + 183 WP_094392952.1 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 306104..472928 166824
- inside Integron - - 307268..474111 166843


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11607.26 Da        Isoelectric Point: 9.9232

>T104326 WP_000802131.1 NZ_CP028893:c414518-414219 [Vibrio cholerae]
MKPFNLTTAAKTDLRDIALFTQRRWGKEQRNIYLKQFDDSFWLLAENPDIGKSCDEIRDGYRKFPQGSHVIFYQQTGSQQ
IRVVRILHKSMDVNPIFGA

Download         Length: 300 bp

>T104326 NZ_CP028893:c414518-414219 [Vibrio cholerae]
ATGAAACCATTTAATCTTACAACTGCAGCCAAAACTGATTTACGTGATATCGCTTTATTTACTCAACGCCGTTGGGGCAA
AGAACAGCGAAACATCTACTTAAAGCAATTTGACGATTCATTTTGGCTTTTGGCTGAAAATCCCGACATCGGCAAATCGT
GTGATGAAATTCGAGATGGTTACCGGAAATTTCCTCAAGGTAGCCATGTAATTTTTTATCAACAAACAGGCAGCCAACAA
ATTAGAGTCGTCCGTATTTTACATAAGAGCATGGATGTTAATCCGATCTTTGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8979.81 Da        Isoelectric Point: 4.1677

>AT104326 WP_002044787.1 NZ_CP028893:c414757-414515 [Vibrio cholerae]
MAKNTSITLGEHFDGFITNQIQSGRYGSASEVIRSALRLLENQETKLQTLRQLLVEGEQSGDADYDLDSFINELDSETNR

Download         Length: 243 bp

>AT104326 NZ_CP028893:c414757-414515 [Vibrio cholerae]
ATGGCTAAGAACACAAGTATTACCCTTGGTGAGCACTTTGATGGTTTTATCACAAACCAAATTCAAAGTGGGCGTTATGG
CTCTGCAAGTGAAGTCATTCGCTCTGCTTTGCGTTTACTCGAAAACCAAGAGACTAAACTGCAGACTCTTCGTCAACTAC
TTGTTGAAGGTGAACAAAGTGGTGACGCTGATTACGACCTTGATAGTTTCATCAATGAACTTGATAGTGAAACTAATCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N8UHD2

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q0JMN6

References