Detailed information of TA system TA104324

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-Phd
• Location: 396051..396629
• Replicon: chromosome
• Accession: NZ_CP028893
• Organism: Vibrio cholerae strain Sa5Y

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: Sa5Y_RS16215
• Protein ID: WP_059261326.1
• Coordinates: 396051..396368 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: Sa5Y_RS16220
• Protein ID: WP_000288450.1
• Coordinates: 396387..396629 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Sa5Y_RS16155	391449..391712	+	264	WP_032473149.1	hypothetical protein	-
Sa5Y_RS16165	391913..392149	-	237	WP_000772130.1	RNA-binding protein	-
Sa5Y_RS16170	392322..392516	+	195	WP_108244014.1	DUF3709 domain-containing protein	-
Sa5Y_RS16175	392537..392770	+	234	WP_108244015.1	DUF3709 domain-containing protein	-
Sa5Y_RS16190	393453..394412	-	960	WP_094393086.1	IS30 family transposase	-
Sa5Y_RS16195	394649..395248	+	600	WP_095464298.1	hypothetical protein	-
Sa5Y_RS16205	395407..395916	+	510	WP_000405988.1	GNAT family N-acetyltransferase	-
Sa5Y_RS16215	396051..396368	-	318	WP_059261326.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Sa5Y_RS16220	396387..396629	-	243	WP_000288450.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
Sa5Y_RS16225	396890..397630	+	741	WP_162298990.1	PhzF family phenazine biosynthesis protein	-
Sa5Y_RS16230	397925..398107	+	183	WP_094393107.1	DUF645 family protein	-
Sa5Y_RS16235	398426..398704	+	279	WP_005526581.1	DUF3601 domain-containing protein	-
Sa5Y_RS16240	398739..399698	-	960	WP_094393086.1	IS30 family transposase	-
Sa5Y_RS16245	399853..399936	+	84	WP_080478874.1	acetyltransferase	-
Sa5Y_RS16250	399949..400308	+	360	WP_095488206.1	VOC family protein	-
Sa5Y_RS16260	400951..401208	+	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
Sa5Y_RS16265	401196..401498	+	303	WP_094393067.1	type II toxin-antitoxin system RelE/ParE family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	306104..472928	166824
	-	inside	Integron	-	-	307268..474111	166843

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12194.02 Da
• Isoelectric Point: 9.5547

>T104324 WP_059261326.1 NZ_CP028893:c396368-396051 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIRNYTIENFAQAQWLKYKSTLLSGFQTLADNPELGKSCEDIYKNGFYFPVGKHMAYYTKEAD
FILIVAVLGQSQLPQKHLTQSRFVS

Nucleotide

• Length: 318 bp

>T104324 NZ_CP028893:c396368-396051 [Vibrio cholerae]
ATGCAAAACAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAGAAACTACACCATTGAAAATTT
CGCTCAAGCACAATGGCTAAAATATAAATCGACCTTGCTTTCAGGTTTCCAGACTCTAGCGGATAATCCAGAGCTAGGAA
AAAGCTGTGAAGATATTTACAAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAGAC
TTCATTCTCATCGTCGCTGTATTAGGGCAATCACAGCTGCCCCAGAAACATCTCACACAATCACGTTTCGTTTCTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8987.28 Da
• Isoelectric Point: 5.0491

>AT104324 WP_000288450.1 NZ_CP028893:c396629-396387 [Vibrio cholerae]
MYTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Nucleotide

• Length: 243 bp

>AT104324 NZ_CP028893:c396629-396387 [Vibrio cholerae]
ATGTACACACTAACAGCAAATGATGCTAAACGAAATTTTGGAGAACTTCTTCTAAGCGCACAGCGCGAGCCTGTCATAAT
CAGCAAAAACAGTAAAAATACTGTCGTTGTCATGTCCATTAAGGATTTTGAAGAACTTGAAGCCATGAAACTCGATTATC
TTAAACACTGCTTTGAGTCCGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCTACTTTTCTAAACACCCTT
TAA