Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafQ-RelB |
| Location | 385827..386367 | Replicon | chromosome |
| Accession | NZ_CP028893 | ||
| Organism | Vibrio cholerae strain Sa5Y | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A151JGK8 |
| Locus tag | Sa5Y_RS16090 | Protein ID | WP_000277238.1 |
| Coordinates | 385827..386096 (-) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9KML3 |
| Locus tag | Sa5Y_RS16095 | Protein ID | WP_001258569.1 |
| Coordinates | 386089..386367 (-) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| Sa5Y_RS16035 | 380891..381613 | + | 723 | WP_108244010.1 | hypothetical protein | - |
| Sa5Y_RS16050 | 381919..382097 | + | 179 | Protein_379 | DUF645 family protein | - |
| Sa5Y_RS20295 | 382461..382632 | + | 172 | Protein_380 | DUF645 family protein | - |
| Sa5Y_RS16065 | 382834..383298 | + | 465 | WP_108244011.1 | GNAT family N-acetyltransferase | - |
| Sa5Y_RS16070 | 383756..383959 | + | 204 | WP_108244012.1 | DUF3265 domain-containing protein | - |
| Sa5Y_RS16075 | 383919..384455 | + | 537 | WP_042989109.1 | GNAT family N-acetyltransferase | - |
| Sa5Y_RS16080 | 384610..385005 | + | 396 | WP_032473749.1 | DUF3465 domain-containing protein | - |
| Sa5Y_RS20205 | 385072..385167 | + | 96 | WP_162843091.1 | acetyltransferase | - |
| Sa5Y_RS16085 | 385157..385690 | + | 534 | WP_032475832.1 | GNAT family N-acetyltransferase | - |
| Sa5Y_RS16090 | 385827..386096 | - | 270 | WP_000277238.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| Sa5Y_RS16095 | 386089..386367 | - | 279 | WP_001258569.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| Sa5Y_RS16105 | 386653..386931 | + | 279 | WP_060780626.1 | DUF3709 domain-containing protein | - |
| Sa5Y_RS16110 | 387201..388025 | + | 825 | WP_000130121.1 | hypothetical protein | - |
| Sa5Y_RS16115 | 388168..388746 | + | 579 | WP_162298936.1 | DJ-1/PfpI family protein | - |
| Sa5Y_RS16125 | 389042..389224 | + | 183 | WP_094392974.1 | DUF645 family protein | - |
| Sa5Y_RS20210 | 389338..389433 | + | 96 | WP_088129403.1 | acetyltransferase | - |
| Sa5Y_RS16135 | 389465..389864 | + | 400 | Protein_394 | VOC family protein | - |
| Sa5Y_RS16145 | 390311..390470 | + | 160 | Protein_395 | DUF3265 domain-containing protein | - |
| Sa5Y_RS16150 | 390543..391256 | + | 714 | WP_000123659.1 | Fic family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 306104..472928 | 166824 | |
| - | inside | Integron | - | - | 307268..474111 | 166843 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10406.11 Da Isoelectric Point: 9.5084
>T104323 WP_000277238.1 NZ_CP028893:c386096-385827 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF
Download Length: 270 bp
>T104323 NZ_CP028893:c386096-385827 [Vibrio cholerae]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10088.58 Da Isoelectric Point: 6.0728
>AT104323 WP_001258569.1 NZ_CP028893:c386367-386089 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV
Download Length: 279 bp
>AT104323 NZ_CP028893:c386367-386089 [Vibrio cholerae]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A151JGK8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A151KTP9 |