Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 345101..345629 Replicon chromosome
Accession NZ_CP028893
Organism Vibrio cholerae strain Sa5Y

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag Sa5Y_RS15645 Protein ID WP_000221352.1
Coordinates 345101..345391 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag Sa5Y_RS15650 Protein ID WP_000213183.1
Coordinates 345381..345629 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Sa5Y_RS15575 340784..340963 + 180 WP_108243971.1 DUF645 family protein -
Sa5Y_RS15590 341327..341497 + 171 WP_108244108.1 DUF645 family protein -
Sa5Y_RS15600 341802..341999 + 198 WP_162298988.1 DUF3709 domain-containing protein -
Sa5Y_RS15605 342466..342699 + 234 WP_094393026.1 DUF3709 domain-containing protein -
Sa5Y_RS15610 342888..342980 + 93 WP_108243974.1 acetyltransferase -
Sa5Y_RS15615 343037..343252 + 216 WP_108243975.1 TIGR02450 family Trp-rich protein -
Sa5Y_RS15620 343410..343766 + 357 Protein_309 VOC family protein -
Sa5Y_RS15625 343750..343914 + 165 WP_205411916.1 DUF3265 domain-containing protein -
Sa5Y_RS15630 343916..344356 + 441 WP_108243976.1 hypothetical protein -
Sa5Y_RS15635 344353..344463 + 111 WP_108244109.1 DUF3265 domain-containing protein -
Sa5Y_RS15640 344503..344961 + 459 WP_000650937.1 hypothetical protein -
Sa5Y_RS15645 345101..345391 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Sa5Y_RS15650 345381..345629 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
Sa5Y_RS15655 345986..346204 + 219 Protein_316 DUF645 family protein -
Sa5Y_RS15660 346379..346870 + 492 WP_108243977.1 hypothetical protein -
Sa5Y_RS15665 346902..347007 + 106 Protein_318 hypothetical protein -
Sa5Y_RS15670 347053..347235 + 183 WP_108243978.1 DUF645 family protein -
Sa5Y_RS15675 347436..347822 + 387 WP_029628680.1 MmcQ/YjbR family DNA-binding protein -
Sa5Y_RS20075 348127..348294 + 168 Protein_321 DUF645 family protein -
Sa5Y_RS15690 348489..348971 + 483 WP_095474232.1 GNAT family N-acetyltransferase -
Sa5Y_RS15695 349265..349432 + 168 WP_108244110.1 DUF645 family protein -
Sa5Y_RS15700 349549..349743 + 195 WP_108243979.1 DUF3709 domain-containing protein -
Sa5Y_RS15705 349737..349997 + 261 WP_205411917.1 DUF3709 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 306104..472928 166824
- inside Integron - - 307268..474111 166843


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T104321 WP_000221352.1 NZ_CP028893:c345391-345101 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T104321 NZ_CP028893:c345391-345101 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTACCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT104321 WP_000213183.1 NZ_CP028893:c345629-345381 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT104321 NZ_CP028893:c345629-345381 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGCGC
CTTCGGAGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTATGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References