Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1050905..1051562 Replicon chromosome
Accession NZ_CP028850
Organism Klebsiella pneumoniae strain 3214

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag DBX64_RS05150 Protein ID WP_002916310.1
Coordinates 1051152..1051562 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag DBX64_RS05145 Protein ID WP_002916312.1
Coordinates 1050905..1051171 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBX64_RS05120 1046113..1047546 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
DBX64_RS05125 1047665..1048393 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
DBX64_RS05130 1048443..1048754 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
DBX64_RS05135 1048918..1049577 + 660 WP_002916317.1 hemolysin III family protein -
DBX64_RS05140 1049676..1050659 - 984 WP_014906951.1 tRNA-modifying protein YgfZ -
DBX64_RS05145 1050905..1051171 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
DBX64_RS05150 1051152..1051562 + 411 WP_002916310.1 protein YgfX Toxin
DBX64_RS05155 1051569..1052090 - 522 WP_002916308.1 flavodoxin FldB -
DBX64_RS05160 1052191..1053087 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
DBX64_RS05165 1053110..1053823 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DBX64_RS05170 1053829..1055562 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T104299 WP_002916310.1 NZ_CP028850:1051152-1051562 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T104299 NZ_CP028850:1051152-1051562 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT104299 WP_002916312.1 NZ_CP028850:1050905-1051171 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT104299 NZ_CP028850:1050905-1051171 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References