Detailed information of TA system TA104281

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1681646..1682258
• Replicon: chromosome
• Accession: NZ_CP028841
• Organism: Streptococcus pyogenes strain CCUG 4207

Toxin (Protein)

• Gene name: parE
• Uniprot ID: J7M9F1
• Locus tag: DB248_RS08930
• Protein ID: WP_010922665.1
• Coordinates: 1681923..1682258 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: DB248_RS08925
• Protein ID: WP_002988079.1
• Coordinates: 1681646..1681933 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DB248_RS08895	1676823..1677806	-	984	WP_002982755.1	tagatose-bisphosphate aldolase	-
DB248_RS08900	1677810..1678739	-	930	WP_010922663.1	tagatose-6-phosphate kinase	-
DB248_RS08905	1678787..1679302	-	516	WP_002988082.1	galactose-6-phosphate isomerase subunit LacB	-
DB248_RS08910	1679337..1679765	-	429	WP_010922664.1	galactose-6-phosphate isomerase subunit LacA	-
DB248_RS08915	1680212..1680985	+	774	WP_002982738.1	DeoR/GlpR family DNA-binding transcription regulator	-
DB248_RS08925	1681646..1681933	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
DB248_RS08930	1681923..1682258	+	336	WP_010922665.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DB248_RS08935	1682410..1682592	+	183	WP_011285716.1	integrase	-
DB248_RS08940	1682926..1683363	+	438	WP_111713473.1	site-specific integrase	-
DB248_RS08945	1683483..1683875	-	393	WP_002982716.1	30S ribosomal protein S9	-
DB248_RS08950	1683896..1684342	-	447	WP_002982710.1	50S ribosomal protein L13	-
DB248_RS08955	1684560..1684766	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
DB248_RS08960	1684763..1685269	-	507	WP_002988070.1	hypothetical protein	-
DB248_RS08965	1685405..1686265	-	861	WP_002982687.1	DegV family protein	-
DB248_RS08970	1686362..1686880	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13185.99 Da
• Isoelectric Point: 5.2144

>T104281 WP_010922665.1 NZ_CP028841:1681923-1682258 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRIVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T104281 NZ_CP028841:1681923-1682258 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGATCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT104281 WP_002988079.1 NZ_CP028841:1681646-1681933 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT104281 NZ_CP028841:1681646-1681933 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAGGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: J7M9F1

Antitoxin

• AlphaFold DB: A0A4U7GX94