Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 4279058..4279692 Replicon chromosome
Accession NZ_CP028834
Organism Streptomyces sp. M2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DBP13_RS19695 Protein ID WP_128802458.1
Coordinates 4279058..4279480 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2T5B9U3
Locus tag DBP13_RS19700 Protein ID WP_020113663.1
Coordinates 4279477..4279692 (-) Length 72 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBP13_RS19670 4274960..4275445 + 486 WP_108010647.1 hypothetical protein -
DBP13_RS19675 4275479..4275919 - 441 WP_206660177.1 hypothetical protein -
DBP13_RS19680 4276030..4277904 - 1875 WP_128802456.1 TerD family protein -
DBP13_RS19685 4278037..4278303 + 267 WP_108010649.1 ribbon-helix-helix domain-containing protein -
DBP13_RS19690 4278300..4278743 + 444 WP_128802457.1 PIN domain-containing protein -
DBP13_RS19695 4279058..4279480 - 423 WP_128802458.1 PIN domain nuclease Toxin
DBP13_RS19700 4279477..4279692 - 216 WP_020113663.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
DBP13_RS19705 4280794..4281420 + 627 WP_128802459.1 hypothetical protein -
DBP13_RS19710 4281485..4282153 + 669 WP_128804477.1 hypothetical protein -
DBP13_RS19715 4282621..4283073 + 453 WP_128802460.1 hypothetical protein -
DBP13_RS19720 4283098..4283313 + 216 WP_128802461.1 cold shock domain-containing protein -
DBP13_RS19725 4283753..4284397 - 645 WP_128802462.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4273792..4284397 10605


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-124)

Antitoxin

(3-49)


Sequences


Toxin        


Download         Length: 141 a.a.        Molecular weight: 15417.29 Da        Isoelectric Point: 4.5641

>T104265 WP_128802458.1 NZ_CP028834:c4279480-4279058 [Streptomyces sp. M2]
VNAAQYLIDTSALARMLRGDAEQYGWDQAAAAGLIATCPITELEFFYSARSAADRTQGIDDMRLLFGWVPVDDRAYDRAW
RVQEVLTQRGQHRSAGAVDLVVAATAELQGLTLLHRDRDFECIAAVTGQALQWYGPEAGK

Download         Length: 423 bp

>T104265 NZ_CP028834:c4279480-4279058 [Streptomyces sp. M2]
GTGAACGCCGCGCAGTACCTGATCGACACCAGCGCGCTCGCTCGTATGCTGCGCGGCGACGCCGAGCAGTACGGATGGGA
CCAAGCGGCAGCCGCCGGGCTCATCGCCACCTGCCCCATCACCGAGTTGGAATTCTTCTACAGTGCGCGTTCCGCCGCCG
ACCGCACGCAAGGCATCGACGACATGCGCCTGCTCTTCGGCTGGGTGCCGGTCGACGACCGCGCCTACGACCGTGCCTGG
CGGGTCCAGGAGGTCCTCACTCAGCGCGGGCAGCACCGGAGTGCCGGAGCCGTCGATCTCGTGGTGGCTGCCACGGCCGA
GTTGCAGGGACTGACGTTGCTGCACCGTGACCGGGACTTCGAGTGCATCGCCGCCGTCACCGGCCAGGCGCTCCAGTGGT
ACGGCCCTGAAGCCGGCAAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7995.02 Da        Isoelectric Point: 6.3273

>AT104265 WP_020113663.1 NZ_CP028834:c4279692-4279477 [Streptomyces sp. M2]
MSRTVIDLDDQLVADVAKALGTSTKKETVNTALREVLENRRRALALTRLRASAEEGAFDLDLFEDKGNYRR

Download         Length: 216 bp

>AT104265 NZ_CP028834:c4279692-4279477 [Streptomyces sp. M2]
ATGAGCCGAACCGTGATCGACCTCGACGACCAGCTGGTCGCTGACGTGGCCAAGGCCCTCGGTACCAGCACCAAGAAGGA
GACGGTGAACACCGCCCTGCGCGAGGTGCTGGAGAACCGGCGGCGAGCCCTGGCGCTCACCCGCCTGCGGGCGTCGGCGG
AAGAGGGTGCCTTCGACCTCGATCTCTTCGAGGACAAGGGAAACTACCGCCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A2T5B9U3

References