Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VapB |
Location | 4279058..4279692 | Replicon | chromosome |
Accession | NZ_CP028834 | ||
Organism | Streptomyces sp. M2 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | DBP13_RS19695 | Protein ID | WP_128802458.1 |
Coordinates | 4279058..4279480 (-) | Length | 141 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A2T5B9U3 |
Locus tag | DBP13_RS19700 | Protein ID | WP_020113663.1 |
Coordinates | 4279477..4279692 (-) | Length | 72 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
DBP13_RS19670 | 4274960..4275445 | + | 486 | WP_108010647.1 | hypothetical protein | - |
DBP13_RS19675 | 4275479..4275919 | - | 441 | WP_206660177.1 | hypothetical protein | - |
DBP13_RS19680 | 4276030..4277904 | - | 1875 | WP_128802456.1 | TerD family protein | - |
DBP13_RS19685 | 4278037..4278303 | + | 267 | WP_108010649.1 | ribbon-helix-helix domain-containing protein | - |
DBP13_RS19690 | 4278300..4278743 | + | 444 | WP_128802457.1 | PIN domain-containing protein | - |
DBP13_RS19695 | 4279058..4279480 | - | 423 | WP_128802458.1 | PIN domain nuclease | Toxin |
DBP13_RS19700 | 4279477..4279692 | - | 216 | WP_020113663.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
DBP13_RS19705 | 4280794..4281420 | + | 627 | WP_128802459.1 | hypothetical protein | - |
DBP13_RS19710 | 4281485..4282153 | + | 669 | WP_128804477.1 | hypothetical protein | - |
DBP13_RS19715 | 4282621..4283073 | + | 453 | WP_128802460.1 | hypothetical protein | - |
DBP13_RS19720 | 4283098..4283313 | + | 216 | WP_128802461.1 | cold shock domain-containing protein | - |
DBP13_RS19725 | 4283753..4284397 | - | 645 | WP_128802462.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 4273792..4284397 | 10605 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 141 a.a. Molecular weight: 15417.29 Da Isoelectric Point: 4.5641
>T104265 WP_128802458.1 NZ_CP028834:c4279480-4279058 [Streptomyces sp. M2]
VNAAQYLIDTSALARMLRGDAEQYGWDQAAAAGLIATCPITELEFFYSARSAADRTQGIDDMRLLFGWVPVDDRAYDRAW
RVQEVLTQRGQHRSAGAVDLVVAATAELQGLTLLHRDRDFECIAAVTGQALQWYGPEAGK
VNAAQYLIDTSALARMLRGDAEQYGWDQAAAAGLIATCPITELEFFYSARSAADRTQGIDDMRLLFGWVPVDDRAYDRAW
RVQEVLTQRGQHRSAGAVDLVVAATAELQGLTLLHRDRDFECIAAVTGQALQWYGPEAGK
Download Length: 423 bp
>T104265 NZ_CP028834:c4279480-4279058 [Streptomyces sp. M2]
GTGAACGCCGCGCAGTACCTGATCGACACCAGCGCGCTCGCTCGTATGCTGCGCGGCGACGCCGAGCAGTACGGATGGGA
CCAAGCGGCAGCCGCCGGGCTCATCGCCACCTGCCCCATCACCGAGTTGGAATTCTTCTACAGTGCGCGTTCCGCCGCCG
ACCGCACGCAAGGCATCGACGACATGCGCCTGCTCTTCGGCTGGGTGCCGGTCGACGACCGCGCCTACGACCGTGCCTGG
CGGGTCCAGGAGGTCCTCACTCAGCGCGGGCAGCACCGGAGTGCCGGAGCCGTCGATCTCGTGGTGGCTGCCACGGCCGA
GTTGCAGGGACTGACGTTGCTGCACCGTGACCGGGACTTCGAGTGCATCGCCGCCGTCACCGGCCAGGCGCTCCAGTGGT
ACGGCCCTGAAGCCGGCAAGTGA
GTGAACGCCGCGCAGTACCTGATCGACACCAGCGCGCTCGCTCGTATGCTGCGCGGCGACGCCGAGCAGTACGGATGGGA
CCAAGCGGCAGCCGCCGGGCTCATCGCCACCTGCCCCATCACCGAGTTGGAATTCTTCTACAGTGCGCGTTCCGCCGCCG
ACCGCACGCAAGGCATCGACGACATGCGCCTGCTCTTCGGCTGGGTGCCGGTCGACGACCGCGCCTACGACCGTGCCTGG
CGGGTCCAGGAGGTCCTCACTCAGCGCGGGCAGCACCGGAGTGCCGGAGCCGTCGATCTCGTGGTGGCTGCCACGGCCGA
GTTGCAGGGACTGACGTTGCTGCACCGTGACCGGGACTTCGAGTGCATCGCCGCCGTCACCGGCCAGGCGCTCCAGTGGT
ACGGCCCTGAAGCCGGCAAGTGA
Antitoxin
Download Length: 72 a.a. Molecular weight: 7995.02 Da Isoelectric Point: 6.3273
>AT104265 WP_020113663.1 NZ_CP028834:c4279692-4279477 [Streptomyces sp. M2]
MSRTVIDLDDQLVADVAKALGTSTKKETVNTALREVLENRRRALALTRLRASAEEGAFDLDLFEDKGNYRR
MSRTVIDLDDQLVADVAKALGTSTKKETVNTALREVLENRRRALALTRLRASAEEGAFDLDLFEDKGNYRR
Download Length: 216 bp
>AT104265 NZ_CP028834:c4279692-4279477 [Streptomyces sp. M2]
ATGAGCCGAACCGTGATCGACCTCGACGACCAGCTGGTCGCTGACGTGGCCAAGGCCCTCGGTACCAGCACCAAGAAGGA
GACGGTGAACACCGCCCTGCGCGAGGTGCTGGAGAACCGGCGGCGAGCCCTGGCGCTCACCCGCCTGCGGGCGTCGGCGG
AAGAGGGTGCCTTCGACCTCGATCTCTTCGAGGACAAGGGAAACTACCGCCGGTGA
ATGAGCCGAACCGTGATCGACCTCGACGACCAGCTGGTCGCTGACGTGGCCAAGGCCCTCGGTACCAGCACCAAGAAGGA
GACGGTGAACACCGCCCTGCGCGAGGTGCTGGAGAACCGGCGGCGAGCCCTGGCGCTCACCCGCCTGCGGGCGTCGGCGG
AAGAGGGTGCCTTCGACCTCGATCTCTTCGAGGACAAGGGAAACTACCGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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