104235

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 2160291..2162011 Replicon chromosome
Accession NZ_CP028813
Organism Edwardsiella ictaluri strain MS-17-156

Toxin (Protein)


Gene name pmenT Uniprot ID C5BBX2
Locus tag DBV23_RS10310 Protein ID WP_015872652.1
Coordinates 2160291..2160947 (+) Length 219 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID C5BBX1
Locus tag DBV23_RS10315 Protein ID WP_015872651.1
Coordinates 2160944..2162011 (+) Length 356 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBV23_RS10290 2155414..2156165 + 752 WP_169315013.1 IS5 family transposase -
DBV23_RS10295 2156246..2156485 + 240 WP_015872655.1 hypothetical protein -
DBV23_RS10300 2156524..2158962 + 2439 WP_015872654.1 type I restriction-modification system subunit M -
DBV23_RS10305 2158968..2160278 + 1311 WP_107775303.1 restriction endonuclease subunit S -
DBV23_RS10310 2160291..2160947 + 657 WP_015872652.1 DUF4433 domain-containing protein Toxin
DBV23_RS10315 2160944..2162011 + 1068 WP_015872651.1 macro domain-containing protein Antitoxin
DBV23_RS10320 2162175..2165270 + 3096 WP_015872650.1 HsdR family type I site-specific deoxyribonuclease -
DBV23_RS10325 2165270..2165986 + 717 WP_015872649.1 M48 family metallopeptidase -
DBV23_RS10330 2166217..2166771 - 555 WP_015872648.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2154265..2169655 15390


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(17-217)

Antitoxin

Macro domain

(18-129)


Sequences

Toxin        


Download         Length: 219 a.a.        Molecular weight: 25178.69 Da        Isoelectric Point: 6.9647

>T104235 WP_015872652.1 NZ_CP028813:2160291-2160947 [Edwardsiella ictaluri]
MAYDYSANLNPEKALIWRIVHRDNIPWILDHGLHCGNSPVQAANWINIGNPELIGKRAGHPVPVGMGGTLHDYVPFYFTP
FSPMLMNIHSGRGGITQRPNEEIVILVSNLRNVAAQNIPFVFTDSHAYYNWVNYYTRLDDLNQIDWSILQARDFRRDPDD
PAKFERYQAEALIWKHCPITLLVGMICYNDGVRLQLEQWLSQRNLTMPVHARAGWYFS

Download         Length: 657 bp

>T104235 NZ_CP028813:2160291-2160947 [Edwardsiella ictaluri]
ATGGCTTATGATTACAGCGCCAACCTCAACCCGGAAAAAGCCCTGATCTGGCGCATTGTCCATCGGGATAATATCCCGTG
GATACTGGACCACGGTCTGCACTGCGGCAACAGCCCGGTGCAGGCGGCAAACTGGATCAATATCGGCAACCCGGAACTTA
TCGGCAAACGCGCCGGGCATCCGGTGCCTGTCGGTATGGGCGGGACGCTGCATGACTACGTGCCGTTTTACTTTACCCCC
TTTTCGCCGATGCTGATGAATATCCACAGCGGGCGTGGCGGCATTACGCAGCGCCCCAATGAGGAAATCGTCATTCTGGT
CAGCAACCTGCGAAACGTGGCGGCGCAGAACATCCCCTTCGTGTTTACCGACAGCCACGCCTACTATAACTGGGTCAACT
ACTACACCCGTCTGGACGATCTGAACCAGATCGACTGGTCTATCTTACAGGCGCGGGATTTCCGTCGCGATCCGGACGAT
CCGGCGAAGTTTGAACGCTATCAGGCCGAGGCGTTAATCTGGAAGCACTGCCCCATCACACTGCTGGTCGGGATGATTTG
TTACAACGATGGCGTCAGGTTACAATTAGAGCAGTGGCTGTCGCAACGTAATCTGACAATGCCCGTTCACGCACGGGCCG
GGTGGTACTTCTCATGA

Antitoxin


Download         Length: 356 a.a.        Molecular weight: 40619.75 Da        Isoelectric Point: 5.6965

>AT104235 WP_015872651.1 NZ_CP028813:2160944-2162011 [Edwardsiella ictaluri]
MITYTQGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPDNMKAYADACKQKQVMTGKMFITETGELMGPRWIVNFPTK
QHWRADSRMAWIEDGLQDLRRFLIEENVQSIAIPPLGAGNGGLNWPDVRARIESALGDLQDTEILIYEPTEKYQNVAKSS
GVKKLTPARAMIAELVRRYWVLGMECSLLEIQKLAWLLQRAIEQHQQEDVLKLRFEAHYYGPYAPNLNHLLNALDGTYLK
AEKRIPDSQPLDVIWFNDREKEHINLWLNSEAKAWLPALEQVSQLIDGFESPFGLELLATVDWLLTRGQCQPTLDSVKEG
LHQWPAGEPWASRKIKLFDDKNLQFAINRVMEFHC

Download         Length: 1068 bp

>AT104235 NZ_CP028813:2160944-2162011 [Edwardsiella ictaluri]
ATGATCACATATACACAAGGCAATTTACTGGACGCGCCCGTGGAAGCACTGGTGAATACGGTGAATACCGTCGGTGTCAT
GGGTAAAGGCATCGCGCTGATGTTTAAAGAGCGCTTCCCCGACAATATGAAAGCCTATGCCGACGCCTGCAAACAAAAGC
AGGTGATGACCGGCAAGATGTTTATTACCGAAACCGGCGAGCTGATGGGGCCACGCTGGATCGTCAACTTCCCTACCAAG
CAGCACTGGCGCGCCGACTCCCGCATGGCGTGGATCGAAGACGGTTTGCAGGACTTGCGCCGCTTTTTGATCGAAGAAAA
CGTGCAGTCCATCGCCATTCCCCCGCTGGGCGCGGGCAACGGCGGCCTGAACTGGCCGGATGTCCGGGCGCGGATTGAAT
CTGCGCTGGGCGACCTTCAGGACACGGAAATCCTGATTTATGAGCCTACCGAAAAATACCAGAACGTCGCCAAGAGCAGC
GGCGTAAAAAAGCTCACCCCCGCCAGAGCGATGATCGCTGAACTGGTGCGCCGCTACTGGGTGCTGGGTATGGAGTGCAG
CCTGCTGGAAATCCAGAAGCTGGCATGGCTGCTACAACGCGCCATTGAACAGCACCAGCAGGAGGACGTGCTAAAACTGC
GGTTTGAGGCGCACTATTACGGCCCCTATGCTCCTAACCTGAACCATCTGCTTAACGCGCTGGACGGTACCTATCTGAAA
GCCGAAAAGCGTATCCCGGACAGCCAGCCACTGGATGTGATCTGGTTTAACGATCGGGAAAAAGAACACATCAACCTCTG
GCTGAACAGCGAAGCCAAAGCGTGGTTGCCAGCGCTTGAGCAGGTCAGCCAGTTGATTGACGGTTTTGAATCGCCGTTTG
GTCTGGAGCTGTTGGCGACCGTTGACTGGTTGTTGACCCGGGGACAATGCCAGCCGACGCTGGACTCGGTGAAAGAGGGG
TTGCATCAGTGGCCTGCGGGAGAACCTTGGGCCAGCCGTAAGATAAAGCTGTTTGACGATAAGAATCTGCAATTCGCCAT
TAACCGCGTGATGGAGTTTCATTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C5BBX2

Antitoxin

Source ID Structure
AlphaFold DB C5BBX1

References