Detailed information of TA system TA104234

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 805866..806529
• Replicon: chromosome
• Accession: NZ_CP028813
• Organism: Edwardsiella ictaluri strain MS-17-156

Toxin (Protein)

• Gene name: tad
• Uniprot ID: C5B7U4
• Locus tag: DBV23_RS03910
• Protein ID: WP_015870280.1
• Coordinates: 805866..806210 (+)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: DBV23_RS03915
• Protein ID: WP_015870279.1
• Coordinates: 806212..806529 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DBV23_RS03890	801989..802612	-	624	WP_015870285.1	phosphatidylglycerophosphatase C	-
DBV23_RS03895	802789..803636	+	848	Protein_733	MurR/RpiR family transcriptional regulator	-
DBV23_RS03900	804764..805447	-	684	WP_107775187.1	phage portal protein	-
DBV23_RS03905	805425..805694	+	270	Protein_735	head completion/stabilization protein	-
DBV23_RS03910	805866..806210	+	345	WP_015870280.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DBV23_RS03915	806212..806529	+	318	WP_015870279.1	helix-turn-helix domain-containing protein	Antitoxin
DBV23_RS03920	806562..806939	-	378	WP_015870278.1	type II toxin-antitoxin system death-on-curing family toxin	-
DBV23_RS03930	807169..807348	-	180	WP_071525714.1	hypothetical protein	-
DBV23_RS03935	807576..808327	+	752	WP_169315014.1	IS5 family transposase	-
DBV23_RS19265	808293..808571	-	279	WP_133175613.1	hypothetical protein	-
DBV23_RS03945	809176..809436	+	261	WP_015870274.1	YfhL family 4Fe-4S dicluster ferredoxin	-
DBV23_RS03950	809458..810135	-	678	WP_015870273.1	envelope stress response activation lipoprotein NlpE	-
DBV23_RS03955	810232..810648	-	417	WP_015870272.1	aminoacyl-tRNA hydrolase	-
DBV23_RS03960	810650..811198	-	549	WP_015870271.1	YaeQ family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-86)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 12544.34 Da
• Isoelectric Point: 9.8474

>T104234 WP_015870280.1 NZ_CP028813:805866-806210 [Edwardsiella ictaluri]
MKSLYWVGSTKKDLQSLPEEVQDIFGYALHLAQVGGKHSQTKPLKGFSGAGVLEVVEDFLGDTYRAVYTVKFGDAVYVSH
VFQKKSSSGIATPKLNMDKIRERLKAAENHARGA

Nucleotide

• Length: 345 bp

>T104234 NZ_CP028813:805866-806210 [Edwardsiella ictaluri]
ATGAAGTCACTATATTGGGTTGGTAGTACAAAAAAAGACCTCCAGTCATTGCCTGAAGAAGTACAGGATATTTTCGGCTA
TGCCCTGCATCTGGCACAGGTAGGAGGTAAACACTCACAGACCAAGCCACTGAAGGGGTTTAGTGGAGCTGGCGTACTTG
AGGTAGTAGAAGACTTTCTCGGTGATACTTATCGTGCAGTGTATACCGTTAAGTTCGGTGATGCCGTCTACGTTTCGCAC
GTATTCCAGAAAAAGTCTTCATCGGGAATCGCCACGCCAAAGCTCAATATGGACAAGATCCGCGAACGGCTAAAAGCCGC
AGAAAACCATGCCAGAGGAGCATAA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11480.41 Da
• Isoelectric Point: 10.2058

>AT104234 WP_015870279.1 NZ_CP028813:806212-806529 [Edwardsiella ictaluri]
MSHDIEVSSGNVYVDIGRDDAEEMLLKAQLATTIGNIIKSRSLTQEQAAKLLGMTQPKLSNMLRGQFRGISEAKMLECLT
RLGRDVQIVVGKPRRTPGSVKVVLA

Nucleotide

• Length: 318 bp

>AT104234 NZ_CP028813:806212-806529 [Edwardsiella ictaluri]
ATGAGCCATGATATTGAAGTCAGCAGCGGCAACGTTTATGTCGATATTGGCAGAGATGATGCCGAGGAAATGCTGTTAAA
AGCTCAGCTTGCCACCACTATTGGAAACATCATTAAAAGCCGTAGCCTGACGCAAGAACAAGCAGCAAAACTGCTGGGGA
TGACGCAGCCCAAACTGTCCAATATGCTGCGTGGGCAGTTCCGGGGCATCAGTGAAGCCAAAATGCTGGAATGTCTGACC
CGCTTAGGGCGCGACGTGCAAATCGTGGTTGGAAAGCCGCGCCGGACGCCGGGTAGCGTGAAAGTAGTGTTAGCCTGA

Structures

Toxin

• AlphaFold DB: C5B7U4