Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 587012..587604 Replicon chromosome
Accession NZ_CP028813
Organism Edwardsiella ictaluri strain MS-17-156

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag DBV23_RS02895 Protein ID WP_012847872.1
Coordinates 587401..587604 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C5BCY7
Locus tag DBV23_RS02890 Protein ID WP_015870487.1
Coordinates 587012..587380 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBV23_RS02880 582272..583456 + 1185 WP_015870489.1 efflux RND transporter periplasmic adaptor subunit -
DBV23_RS02885 583500..586652 + 3153 WP_015870488.1 multidrug efflux RND transporter permease subunit -
DBV23_RS02890 587012..587380 + 369 WP_015870487.1 Hha toxicity modulator TomB Antitoxin
DBV23_RS02895 587401..587604 + 204 WP_012847872.1 hemolysin expression modulator Hha Toxin
DBV23_RS02900 587624..587731 - 108 Protein_539 IS5/IS1182 family transposase -
DBV23_RS02915 588709..589038 + 330 WP_015870485.1 MGMT family protein -
DBV23_RS02920 589084..589950 + 867 WP_015870484.1 acyl-CoA thioesterase II -
DBV23_RS02925 589984..591264 - 1281 WP_035610376.1 ammonium transporter AmtB -
DBV23_RS02930 591286..591624 - 339 WP_015870482.1 P-II family nitrogen regulator -
DBV23_RS19245 591727..591894 + 168 WP_015870481.1 hypothetical protein -
DBV23_RS02935 591923..592384 - 462 WP_015870480.1 Lrp/AsnC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T104233 WP_012847872.1 NZ_CP028813:587401-587604 [Edwardsiella ictaluri]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T104233 NZ_CP028813:587401-587604 [Edwardsiella ictaluri]
ATGACAAAAATCGATTATCTGATGAAGTTGCGTAAATGCACGACGCTGGATACTCTGGAACGCGTGATCGAAAAGAACAA
ATACGAACTTTCAGATGATGAGCTGGAAATTTTTTATTCTGCCGCAGATCATCGACTGGCTGAATTAACCATGAATAAAC
TATACGACAAAATTCCGGCAGAAGTTTGGCAATACGTCCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14287.03 Da        Isoelectric Point: 5.4786

>AT104233 WP_015870487.1 NZ_CP028813:587012-587380 [Edwardsiella ictaluri]
MDENTSYQHDISELKYLCDYLYHQGIDVLGESNHGWVSDPTAEVNLQLNELIEHIASIAQSFKIKYPRHSDLAEMLDYYL
DETYALFGTYSISETALRQWLRTKRRMAYCLAHEKRNAALHV

Download         Length: 369 bp

>AT104233 NZ_CP028813:587012-587380 [Edwardsiella ictaluri]
ATGGATGAGAACACTTCTTATCAGCATGACATCTCAGAGTTAAAATACCTGTGTGATTACCTGTATCATCAGGGAATAGA
TGTCTTGGGAGAAAGCAATCACGGCTGGGTCAGCGATCCGACGGCAGAAGTAAATCTACAGCTTAACGAGCTGATTGAGC
ATATTGCCAGCATCGCGCAATCATTTAAGATCAAATATCCGCGTCATTCGGATTTAGCCGAAATGCTGGATTATTATCTG
GATGAAACCTATGCCCTGTTTGGCACCTATAGCATAAGTGAAACGGCGCTCAGGCAATGGTTGCGTACCAAACGTCGGAT
GGCATACTGTCTGGCGCATGAAAAGCGCAACGCTGCCTTACATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB C5BCY7

References