Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 279263..279858 Replicon chromosome
Accession NZ_CP028809
Organism Burkholderia contaminans strain SK875

Toxin (Protein)


Gene name chpB Uniprot ID A0A1E3FP25
Locus tag SK875_RS33240 Protein ID WP_039362634.1
Coordinates 279508..279858 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A0G3Z282
Locus tag SK875_RS33235 Protein ID WP_039362633.1
Coordinates 279263..279514 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SK875_RS33220 274544..275221 + 678 WP_039362629.1 heavy metal response regulator transcription factor -
SK875_RS33225 275218..276678 + 1461 WP_039362631.1 heavy metal sensor histidine kinase -
SK875_RS33230 276910..278730 - 1821 WP_046197074.1 asparagine synthase (glutamine-hydrolyzing) -
SK875_RS33235 279263..279514 + 252 WP_039362633.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SK875_RS33240 279508..279858 + 351 WP_039362634.1 type II toxin-antitoxin system ChpB family toxin Toxin
SK875_RS33245 279982..281511 - 1530 WP_039362750.1 efflux transporter outer membrane subunit -
SK875_RS33250 281543..283003 - 1461 WP_039362635.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 267826..279858 12032


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12403.30 Da        Isoelectric Point: 10.0752

>T104230 WP_039362634.1 NZ_CP028809:279508-279858 [Burkholderia contaminans]
MVRRVKFERGDIVRVSLNPTVGKEQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARYAGFAVPLSGSGTETQGVALV
NMVRTLDLQARGARKVERAPSEVIEDALARLQTILE

Download         Length: 351 bp

>T104230 NZ_CP028809:279508-279858 [Burkholderia contaminans]
ATGGTGAGGCGCGTCAAGTTCGAGAGGGGCGATATTGTGCGCGTTAGCCTGAACCCGACCGTGGGCAAGGAGCAACAAGG
GGATTTTCGCCCCGCGCTCGTTTTGTCGCCTGCTGCGTTCAATGCGCTTGGCGTGGCGCTCGTCGCGCCGATTACGCAGG
GCGGCGAATTCGCGCGATACGCGGGATTCGCTGTGCCCCTCTCGGGTTCGGGCACTGAAACGCAGGGCGTGGCTCTTGTG
AACATGGTTCGCACGCTCGATCTTCAGGCGCGTGGCGCACGTAAGGTCGAGCGCGCTCCGTCCGAAGTGATCGAAGATGC
GCTCGCGCGTCTTCAGACCATTCTCGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8948.19 Da        Isoelectric Point: 4.7204

>AT104230 WP_039362633.1 NZ_CP028809:279263-279514 [Burkholderia contaminans]
MELKIQKWGNSAAVRLPAVLLEQIDASVGSSLNADVRPDGVLLSPARRKYSLDELIAQCDPKAPEPADLAAWGESKPVGH
EAW

Download         Length: 252 bp

>AT104230 NZ_CP028809:279263-279514 [Burkholderia contaminans]
ATGGAACTCAAAATTCAGAAGTGGGGCAACAGCGCCGCAGTCCGGCTTCCGGCCGTGTTGCTTGAGCAAATCGACGCGTC
GGTAGGTAGCTCGCTGAACGCCGATGTGCGCCCCGATGGTGTGTTGCTTTCGCCAGCCCGGCGCAAGTATTCACTGGATG
AACTGATTGCGCAGTGCGATCCGAAGGCCCCGGAACCCGCCGACCTTGCCGCGTGGGGCGAATCCAAGCCGGTGGGGCAT
GAAGCATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3FP25

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3Z282

References