Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 1056861..1057498 Replicon chromosome
Accession NZ_CP028807
Organism Burkholderia contaminans strain SK875

Toxin (Protein)


Gene name vapC Uniprot ID A0A228K4S8
Locus tag SK875_RS05195 Protein ID WP_039351354.1
Coordinates 1056861..1057262 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A1E3FXY0
Locus tag SK875_RS05200 Protein ID WP_039351357.1
Coordinates 1057262..1057498 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SK875_RS05185 1054235..1055371 + 1137 WP_039351348.1 alginate lyase family protein -
SK875_RS05190 1055402..1056790 + 1389 WP_039351351.1 L-serine ammonia-lyase -
SK875_RS05195 1056861..1057262 - 402 WP_039351354.1 type II toxin-antitoxin system VapC family toxin Toxin
SK875_RS05200 1057262..1057498 - 237 WP_039351357.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SK875_RS05210 1057859..1059562 + 1704 WP_039351360.1 thiamine pyrophosphate-binding protein -
SK875_RS05215 1059559..1060656 + 1098 WP_039351363.1 ADP-heptose--LPS heptosyltransferase -
SK875_RS05220 1060774..1061805 - 1032 WP_039351365.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14880.98 Da        Isoelectric Point: 4.7249

>T104224 WP_039351354.1 NZ_CP028807:c1057262-1056861 [Burkholderia contaminans]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVAACASPARERGNLAALIDDIPVAPFDVAAAQA
YGPVREATRERKKDHLDKLIAAHAVSLDVVLVTNNERDFVSYPGLRLENWLDD

Download         Length: 402 bp

>T104224 NZ_CP028807:c1057262-1056861 [Burkholderia contaminans]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTACCTGATGAAGAATCAGCCGGAGCAGGTTGCGAGACGGTTTGC
GCAGTGCTACACGGGGGACGTCGTGATGTCGGCGATCACGTACGCCGAGCTCGAGTACGGCGTCGCGGCGTGCGCGAGCC
CTGCGCGGGAGCGCGGCAATCTTGCCGCGCTGATCGACGACATTCCCGTTGCGCCGTTCGACGTCGCGGCCGCGCAAGCG
TATGGCCCGGTCCGCGAGGCAACCCGGGAGCGGAAGAAGGATCACCTCGACAAGCTGATCGCCGCGCATGCGGTGTCGCT
CGATGTCGTACTCGTGACCAACAACGAGCGGGATTTCGTGAGCTATCCGGGACTGCGGCTGGAGAACTGGCTGGACGATT
GA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9008.13 Da        Isoelectric Point: 6.4720

>AT104224 WP_039351357.1 NZ_CP028807:c1057498-1057262 [Burkholderia contaminans]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERIGDEIRIRPARRPLTRVLEKFAKFGPDFMADGRGDHEQADREGL

Download         Length: 237 bp

>AT104224 NZ_CP028807:c1057498-1057262 [Burkholderia contaminans]
ATGCATACGACGAGGGTATTTCGGAACGGCAACTCGCAGGCCGTGCGAATTCCTGCCGACCTTGCCTATGAACGCAGCGA
TATCGAACTGGAAATCGAGCGCATTGGTGACGAAATCCGCATTCGGCCGGCGCGGCGGCCGTTGACCCGCGTCCTTGAGA
AATTCGCTAAATTCGGGCCGGATTTCATGGCGGATGGGCGCGGTGACCACGAGCAGGCCGATCGCGAGGGTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A228K4S8

Antitoxin

Source ID Structure
AlphaFold DB A0A1E3FXY0

References