Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 3021..3601 Replicon plasmid p1_085072
Accession NZ_CP028801
Organism Klebsiella pneumoniae strain WCHKP7E2

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag B7D49_RS00030 Protein ID WP_071177730.1
Coordinates 3287..3601 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag B7D49_RS00025 Protein ID WP_000093040.1
Coordinates 3021..3299 (+) Length 93 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7D49_RS00010 1594..1839 + 246 WP_032440458.1 hypothetical protein -
B7D49_RS00015 2113..2484 + 372 WP_001237044.1 cell envelope integrity protein TolA -
B7D49_RS00020 2481..2687 + 207 Protein_3 TonB family protein -
B7D49_RS00025 3021..3299 + 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
B7D49_RS00030 3287..3601 + 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B7D49_RS00035 3765..4193 + 429 WP_001140599.1 hypothetical protein -
B7D49_RS00040 4219..4398 + 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
B7D49_RS00045 4425..4955 - 531 WP_071177729.1 hypothetical protein -
B7D49_RS00050 4962..5693 - 732 WP_071177728.1 replication-relaxation family protein -
B7D49_RS00055 5693..7657 - 1965 WP_071177727.1 TraM recognition domain-containing protein -
B7D49_RS00060 7685..7990 - 306 WP_071994323.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..10060 10060


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T104202 WP_071177730.1 NZ_CP028801:3287-3601 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

>T104202 NZ_CP028801:3287-3601 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT104202 WP_000093040.1 NZ_CP028801:3021-3299 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp

>AT104202 NZ_CP028801:3021-3299 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References