Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1633556..1635192 Replicon chromosome
Accession NZ_CP028800
Organism Acinetobacter junii strain WCHAJ59

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CDG57_RS07945 Protein ID WP_087540912.1
Coordinates 1633556..1634887 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CDG57_RS07950 Protein ID WP_087540911.1
Coordinates 1634884..1635192 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDG57_RS07920 1628953..1629948 + 996 WP_004911105.1 DUF1852 domain-containing protein -
CDG57_RS07925 1629972..1631000 + 1029 WP_087540915.1 methionine synthase -
CDG57_RS07930 1631187..1631681 + 495 WP_004954405.1 flavin reductase -
CDG57_RS07935 1631723..1632520 + 798 WP_039907982.1 sulfite exporter TauE/SafE family protein -
CDG57_RS07940 1632580..1633278 - 699 WP_087540914.1 DUF1826 domain-containing protein -
CDG57_RS07945 1633556..1634887 + 1332 WP_087540912.1 HipA domain-containing protein Toxin
CDG57_RS07950 1634884..1635192 + 309 WP_087540911.1 helix-turn-helix domain-containing protein Antitoxin
CDG57_RS07955 1635270..1635401 - 132 Protein_1485 VF530 family DNA-binding protein -
CDG57_RS07960 1635674..1637971 - 2298 WP_087540909.1 hypothetical protein -
CDG57_RS07965 1637971..1639224 - 1254 WP_087540908.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1381966..1782190 400224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-363)

Antitoxin

Cro/C1-type helix-turn-helix domain

(29-82)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 50699.39 Da        Isoelectric Point: 4.8438

>T104201 WP_087540912.1 NZ_CP028800:1633556-1634887 [Acinetobacter junii]
MKKLTIQALLDQSWFDIAELTLLEPKLGSASASELAYELEYAIHNLDKRDEHACGLSLPVQLLIKHESSSWFGFLDDIVP
SGAARRYWVNFLGLQRLTYAEQDSILLEKGGIAPVGNLRIKEALPPINPESTLHLRYFSQSDVADRNVDFLEYAQQMGAI
SGGATGAGGEAPKLLIRATKDQNIWIDTYQQNFDQPDQHYLVKFPRNNRSEIDCNILRAEYYYYQELKELGFNTIETTEM
KLIEGEKYPSLWLPRFDVEWHNQKWHRYGLESVYSVLNKASGSHLNHFEVIENLCNLLISIDSEFDSEQFVCEWLQRDLL
NIIFGNSDNHGRNTSFLKQSGKISLAPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYQWEQITQKLAHLCDPNLSLTTLK
SLASHLVGLKQRLIDKGVPKQIMEIPALSFDYVEAKLERWELL

Download         Length: 1332 bp

>T104201 NZ_CP028800:1633556-1634887 [Acinetobacter junii]
ATGAAAAAATTAACAATACAGGCGTTACTTGATCAAAGTTGGTTTGATATTGCTGAACTAACATTATTAGAACCTAAACT
AGGCTCAGCAAGTGCCAGTGAATTAGCTTACGAGTTAGAATACGCAATCCACAATTTGGACAAGCGAGATGAGCATGCCT
GTGGTTTGTCGCTACCTGTACAACTACTAATAAAACATGAATCTAGTTCATGGTTTGGTTTTTTAGATGATATTGTTCCA
TCAGGTGCTGCACGCCGTTATTGGGTGAATTTTCTAGGTCTACAAAGACTAACGTATGCTGAGCAAGATAGTATTTTATT
AGAAAAAGGTGGCATCGCACCCGTAGGCAATTTGAGAATAAAAGAAGCTCTTCCACCAATCAATCCTGAATCGACTCTGC
ATTTACGTTATTTTAGTCAAAGTGATGTTGCTGACCGAAATGTAGATTTTCTTGAATATGCACAGCAAATGGGTGCAATT
AGTGGTGGTGCAACAGGAGCGGGTGGTGAAGCTCCTAAATTATTGATTCGTGCTACAAAAGATCAAAATATTTGGATTGA
TACTTATCAACAAAACTTTGATCAACCTGATCAACACTATCTAGTTAAATTCCCTAGAAATAATCGTAGTGAGATCGACT
GTAATATTCTCAGAGCAGAATACTATTACTATCAAGAGCTAAAAGAGTTGGGTTTCAATACCATTGAAACTACAGAAATG
AAGCTGATCGAAGGTGAAAAATATCCATCATTATGGCTACCAAGATTTGATGTTGAATGGCACAACCAAAAATGGCATCG
TTATGGACTTGAATCTGTCTATTCCGTATTAAATAAAGCTTCGGGTAGCCATCTCAATCACTTTGAAGTGATTGAAAATC
TATGCAATTTACTGATATCTATTGATTCAGAGTTTGATTCAGAACAATTCGTTTGTGAGTGGTTACAGCGAGATTTACTC
AATATTATTTTTGGTAATTCTGATAATCATGGGCGAAATACTTCATTTCTAAAACAATCTGGAAAAATTTCGCTTGCTCC
AATTTATGATTTTGCTCCAATGAAAGCTGATCCAGAAGTTGTCACAAGATCAACAACTTGGGGAAGTCCTTATGAGGAAG
GAGGAGAATATCAATGGGAGCAAATTACACAAAAGCTTGCACATTTATGCGATCCGAATTTGTCTCTAACTACATTGAAA
TCTTTAGCAAGTCATCTTGTTGGGCTAAAACAAAGATTAATAGATAAAGGTGTACCAAAACAAATTATGGAGATTCCAGC
GCTTTCATTTGACTATGTTGAAGCTAAATTAGAAAGATGGGAACTATTATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11722.67 Da        Isoelectric Point: 9.9970

>AT104201 WP_087540911.1 NZ_CP028800:1634884-1635192 [Acinetobacter junii]
MNTKNQTQDRQQVLIDLYMQYLLNEITLGQLLAYLRKNILSMSQEQYANLVGVSRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVRKIIKPSE

Download         Length: 309 bp

>AT104201 NZ_CP028800:1634884-1635192 [Acinetobacter junii]
ATGAATACAAAAAATCAGACTCAAGATCGTCAACAAGTTCTTATTGATCTATATATGCAGTACTTATTGAATGAAATCAC
ATTAGGGCAATTATTGGCGTATTTGCGAAAAAATATTCTTAGTATGTCTCAGGAACAATATGCAAATTTAGTCGGTGTAA
GTCGCAGGACGTTAACTGATATTGAACAGGACAAAGGAAAACTTACGCAATCTGTTTTAGACAAGGTATTTAAACCACTT
GGATTGAAAGCAGGACTTGTACCGACTCATGAGCATATTGTGAGAAAGATCATTAAACCATCAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References