Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 889109..889763 Replicon chromosome
Accession NZ_CP028797
Organism Klebsiella pneumoniae strain WCHKP040035

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag C6M51_RS05915 Protein ID WP_004144731.1
Coordinates 889356..889763 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag C6M51_RS05910 Protein ID WP_002916312.1
Coordinates 889109..889375 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6M51_RS05885 884289..885722 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
C6M51_RS05890 885841..886569 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
C6M51_RS05895 886619..886930 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
C6M51_RS05900 887094..887729 + 636 WP_101963437.1 hemolysin III family protein -
C6M51_RS05905 887880..888863 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
C6M51_RS05910 889109..889375 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
C6M51_RS05915 889356..889763 + 408 WP_004144731.1 protein YgfX Toxin
C6M51_RS05920 889770..890291 - 522 WP_002916308.1 flavodoxin FldB -
C6M51_RS05925 890392..891288 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
C6M51_RS05930 891311..892024 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C6M51_RS05935 892030..893763 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T104181 WP_004144731.1 NZ_CP028797:889356-889763 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T104181 NZ_CP028797:889356-889763 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT104181 WP_002916312.1 NZ_CP028797:889109-889375 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT104181 NZ_CP028797:889109-889375 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References