Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 160052..160803 Replicon plasmid pOXA1_020030
Accession NZ_CP028791
Organism Klebsiella pneumoniae strain WCHKP020030

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag C6M02_RS01920 Protein ID WP_014386536.1
Coordinates 160052..160534 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag C6M02_RS01925 Protein ID WP_004902250.1
Coordinates 160525..160803 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6M02_RS01880 155674..156321 - 648 WP_014386537.1 EcsC family protein -
C6M02_RS01885 156348..156893 - 546 Protein_189 hypothetical protein -
C6M02_RS01890 156948..157645 + 698 Protein_190 IS1 family transposase -
C6M02_RS01895 157662..157880 - 219 Protein_191 hypothetical protein -
C6M02_RS01900 157981..158373 - 393 WP_032442757.1 hypothetical protein -
C6M02_RS01905 158478..159017 - 540 WP_004902239.1 hypothetical protein -
C6M02_RS01910 159458..159838 + 381 WP_004902242.1 hypothetical protein -
C6M02_RS01915 159839..160051 - 213 WP_071889220.1 hypothetical protein -
C6M02_RS01920 160052..160534 - 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
C6M02_RS01925 160525..160803 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
C6M02_RS01930 160922..161134 - 213 WP_004902255.1 hypothetical protein -
C6M02_RS01935 161242..161583 - 342 WP_004902257.1 hypothetical protein -
C6M02_RS01940 161683..161973 - 291 WP_072196711.1 hypothetical protein -
C6M02_RS01945 162144..162416 - 273 WP_017900808.1 hypothetical protein -
C6M02_RS01950 162413..162865 - 453 WP_017900807.1 hypothetical protein -
C6M02_RS01955 163524..163979 - 456 WP_001166628.1 Hg(II)-responsive transcriptional regulator -
C6M02_RS01960 164051..164416 + 366 WP_001294656.1 mercuric ion transporter MerT -
C6M02_RS01965 164432..164707 + 276 WP_000732275.1 mercury resistance system periplasmic binding protein MerP -
C6M02_RS01970 164735..165160 + 426 WP_000522996.1 organomercurial transporter MerC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr iucA / iucB / iucC / iucD / iutA / rmpA2 1..288222 288222
- flank IS/Tn - - 157352..157645 293


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T104152 WP_014386536.1 NZ_CP028791:c160534-160052 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

>T104152 NZ_CP028791:c160534-160052 [Klebsiella pneumoniae]
ATGGGAATGAGAGCGCCTGAATCCCTGACGGCTGAACATAACATCGCTGAGTTCTGCTGCCAGGAGCCTGCCCTTAATGA
GTGGTTAAAGAAGAAGGCTCTCAGAAACCACAGTACCGGCATTTCCCGTGTCTATGTCGTCTGCGCAGAAAACACTAACC
GGGTCATCGGTTATTATTGTTTATCTTCGGGTAGCGTCCACCGTAACACAGTGCCTGGGGCCTATAGACGCAACGCGCCT
GATGTCATTCCAGTCATTGTTTTGGGACGGCTTGCCATCGACCAGGCCTGGGCCGGGAATGGGCTTGGTGCCGCACTTCT
TAAGGATGCTATATACCGTACGCAAAACATAGCCTTTCAGGTCGGGGTGAGAGCACTGGCCGTGCATGCGCTGAATGAAG
AAGTTAAATGTTTTTACACCCGTTTTGGCTTTGAGCCTTCCATAGTCAACACGCTGACATTGTTATTCCCGATAAAAGTC
TGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT104152 WP_004902250.1 NZ_CP028791:c160803-160525 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp

>AT104152 NZ_CP028791:c160803-160525 [Klebsiella pneumoniae]
ATGAAACCAGACGTTCGTGAAGCTCCGATTAATATCCGGGCCAAAACATCACAGCGTGACCTGATCGACATGGCCGCAAG
CCTGGTCTCAAAATCACGGACTGATTTTATGCTTGAGGTTGCCTGCAGGGAGGCACAGGACATTCTGCTTGATCAACGCC
TGTTCCTCCTCAATGACAATCAGTTTGAGGCGTTTATTGAAGAGCTTGACGCCCCAATAACGCCGGAGCGCCAGGCGCGA
ATCGATAACCTGATGAACCGCAAATCACCATGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References