Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4836491..4838172 Replicon chromosome
Accession NZ_CP028787
Organism Klebsiella pneumoniae strain SCKP020049

Toxin (Protein)


Gene name mosT Uniprot ID A0A483YLF8
Locus tag CLQ68_RS25525 Protein ID WP_019724882.1
Coordinates 4836491..4837408 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag CLQ68_RS25530 Protein ID WP_004177809.1
Coordinates 4837414..4838172 (-) Length 253 a.a.

Genomic Context


CLQ68_RS25505CLQ68_RS25510CLQ68_RS25515CLQ68_RS25520CLQ68_RS25540CLQ68_RS25545CLQ68_RS25525CLQ68_RS25530CLQ68_RS25535
Location: 4831797..4833317 (1521 bp)
Type: Others
Protein ID: WP_004210021.1
Location: 4833314..4834312 (999 bp)
Type: Others
Protein ID: WP_002885172.1
Location: 4834343..4835284 (942 bp)
Type: Others
Protein ID: WP_002885156.1
Location: 4835359..4836366 (1008 bp)
Type: Others
Protein ID: WP_064152101.1
Location: 4839259..4841406 (2148 bp)
Type: Others
Protein ID: WP_077625403.1
Location: 4841636..4842322 (687 bp)
Type: Others
Protein ID: WP_004151733.1
Location: 4836491..4837408 (918 bp)
Type: Toxin
Protein ID: WP_019724882.1
Location: 4837414..4838172 (759 bp)
Type: Antitoxin
Protein ID: WP_004177809.1
Location: 4838258..4838986 (729 bp)
Type: Others
Protein ID: WP_002885152.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CLQ68_RS255054831797..4833317+1521WP_004210021.1sugar ABC transporter ATP-binding protein-
CLQ68_RS255104833314..4834312+999WP_002885172.1ribose ABC transporter permease-
CLQ68_RS255154834343..4835284+942WP_002885156.1ABC transporter substrate-binding protein-
CLQ68_RS255204835359..4836366+1008WP_064152101.1carbohydrate kinase family protein-
CLQ68_RS255254836491..4837408-918WP_019724882.1nucleotidyl transferase AbiEii/AbiGii toxin family proteinToxin
CLQ68_RS255304837414..4838172-759WP_004177809.1type IV toxin-antitoxin system AbiEi family antitoxinAntitoxin
CLQ68_RS255354838258..4838986-729WP_002885152.1response regulator transcription factor-
CLQ68_RS255404839259..4841406+2148WP_077625403.1formate dehydrogenase subunit alpha-
CLQ68_RS255454841636..4842322+687WP_004151733.1sel1 repeat family protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 306 a.a.        Molecular weight: 34653.14 Da        Isoelectric Point: 5.4707

>T104143 WP_019724882.1 NZ_CP028787:c4837408-4836491 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CITQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T104143 NZ_CP028787:c4837408-4836491 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTATCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT104143 WP_004177809.1 NZ_CP028787:c4838172-4837414 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT104143 NZ_CP028787:c4838172-4837414 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATATGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A483YLF8


Antitoxin

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Source
ID
Structure
AlphaFold DBA6TH05

References