Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4681015..4681531 Replicon chromosome
Accession NZ_CP028787
Organism Klebsiella pneumoniae strain SCKP020049

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag CLQ68_RS24715 Protein ID WP_004178374.1
Coordinates 4681015..4681299 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag CLQ68_RS24720 Protein ID WP_002886901.1
Coordinates 4681289..4681531 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLQ68_RS24695 4676410..4676718 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
CLQ68_RS28640 4676803..4676976 + 174 WP_032412860.1 hypothetical protein -
CLQ68_RS24700 4676979..4677722 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
CLQ68_RS24705 4678079..4680217 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
CLQ68_RS24710 4680547..4681011 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CLQ68_RS24715 4681015..4681299 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CLQ68_RS24720 4681289..4681531 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CLQ68_RS24725 4681609..4683519 - 1911 WP_004152270.1 BglG family transcription antiterminator -
CLQ68_RS24730 4683542..4684696 - 1155 WP_002886900.1 lactonase family protein -
CLQ68_RS24735 4684763..4685503 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T104142 WP_004178374.1 NZ_CP028787:c4681299-4681015 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T104142 NZ_CP028787:c4681299-4681015 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCTGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT104142 WP_002886901.1 NZ_CP028787:c4681531-4681289 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT104142 NZ_CP028787:c4681531-4681289 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References