Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 737584..738359 Replicon chromosome
Accession NZ_CP028783
Organism Klebsiella pneumoniae subsp. pneumoniae strain SCKP020046

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag CLQ69_RS05280 Protein ID WP_004150910.1
Coordinates 737874..738359 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag CLQ69_RS05275 Protein ID WP_004150912.1
Coordinates 737584..737877 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLQ69_RS05255 732792..733394 - 603 WP_002916735.1 short chain dehydrogenase -
CLQ69_RS05260 733492..734403 + 912 WP_004188550.1 LysR family transcriptional regulator -
CLQ69_RS05265 734404..735552 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
CLQ69_RS05270 735563..736933 - 1371 WP_004150913.1 cystathionine beta-synthase -
CLQ69_RS05275 737584..737877 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
CLQ69_RS05280 737874..738359 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
CLQ69_RS05285 738724..738918 + 195 WP_108429383.1 hypothetical protein -
CLQ69_RS05290 738956..739972 - 1017 WP_001310555.1 IS5-like element IS5 family transposase -
CLQ69_RS05295 739938..740009 + 72 Protein_753 acid-resistance protein -
CLQ69_RS05300 740262..740855 + 594 WP_004188553.1 hypothetical protein -
CLQ69_RS05305 740952..741168 + 217 Protein_755 IS3 family transposase -
CLQ69_RS05310 741316..741501 + 186 WP_085763813.1 hypothetical protein -
CLQ69_RS05315 741611..742483 + 873 WP_004188557.1 ParA family protein -
CLQ69_RS05320 742483..742866 + 384 WP_004150906.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T104111 WP_004150910.1 NZ_CP028783:737874-738359 [Klebsiella pneumoniae subsp. pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T104111 NZ_CP028783:737874-738359 [Klebsiella pneumoniae subsp. pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT104111 WP_004150912.1 NZ_CP028783:737584-737877 [Klebsiella pneumoniae subsp. pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT104111 NZ_CP028783:737584-737877 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References