Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2305292..2305818 | Replicon | chromosome |
| Accession | NZ_CP028769 | ||
| Organism | Escherichia coli strain A5 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | AOY56_RS11150 | Protein ID | WP_000323025.1 |
| Coordinates | 2305531..2305818 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | AOY56_RS11145 | Protein ID | WP_000534858.1 |
| Coordinates | 2305292..2305531 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AOY56_RS11105 (2300478) | 2300478..2300705 | + | 228 | WP_000476993.1 | Cro/CI family transcriptional regulator | - |
| AOY56_RS11110 (2300689) | 2300689..2301210 | + | 522 | WP_000705349.1 | toxin YdaT family protein | - |
| AOY56_RS11115 (2301191) | 2301191..2302156 | + | 966 | WP_000054506.1 | hypothetical protein | - |
| AOY56_RS11120 (2302197) | 2302197..2302616 | + | 420 | WP_001151195.1 | DUF977 family protein | - |
| AOY56_RS11125 (2302671) | 2302671..2303768 | + | 1098 | Protein_2183 | ISNCY family transposase | - |
| AOY56_RS11130 (2303841) | 2303841..2303990 | + | 150 | WP_011443592.1 | protein YdfW | - |
| AOY56_RS11135 (2304427) | 2304427..2304759 | - | 333 | WP_001349760.1 | FlxA-like family protein | - |
| AOY56_RS11140 (2304962) | 2304962..2305267 | - | 306 | WP_001326990.1 | protein YdfV | - |
| AOY56_RS11145 (2305292) | 2305292..2305531 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| AOY56_RS11150 (2305531) | 2305531..2305818 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| AOY56_RS11155 (2305890) | 2305890..2306045 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| AOY56_RS11160 (2306262) | 2306262..2306513 | + | 252 | WP_000980994.1 | protein Rem | - |
| AOY56_RS11165 (2306580) | 2306580..2306858 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| AOY56_RS11170 (2306860) | 2306860..2307909 | + | 1050 | WP_063087587.1 | DUF968 domain-containing protein | - |
| AOY56_RS11175 (2307923) | 2307923..2308675 | + | 753 | WP_001047135.1 | antitermination protein | - |
| AOY56_RS11180 (2308953) | 2308953..2309042 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| AOY56_RS11185 (2309097) | 2309097..2309309 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| AOY56_RS11190 (2309610) | 2309610..2309825 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| AOY56_RS11195 (2310189) | 2310189..2310359 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| AOY56_RS11200 (2310579) | 2310579..2310794 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2282245..2358766 | 76521 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T104022 WP_000323025.1 NZ_CP028769:2305531-2305818 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T104022 NZ_CP028769:2305531-2305818 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT104022 WP_000534858.1 NZ_CP028769:2305292-2305531 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT104022 NZ_CP028769:2305292-2305531 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|