Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4669785..4670829 Replicon chromosome
Accession NZ_CP028768
Organism Escherichia coli strain A6

Toxin (Protein)


Gene name panT Uniprot ID A0A0K4KFL7
Locus tag AOY57_RS23130 Protein ID WP_000019185.1
Coordinates 4669785..4670333 (-) Length 183 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A839B6W4
Locus tag AOY57_RS23135 Protein ID WP_000287252.1
Coordinates 4670356..4670829 (-) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY57_RS23080 (4665481) 4665481..4665843 + 363 WP_000135680.1 protein YfdP -
AOY57_RS23085 (4665909) 4665909..4666733 + 825 WP_201478759.1 DUF2303 family protein -
AOY57_RS23090 (4666861) 4666861..4667397 + 537 WP_201478760.1 5'-deoxynucleotidase -
AOY57_RS23095 (4667388) 4667388..4667750 + 363 WP_181816936.1 hypothetical protein -
AOY57_RS23100 (4667747) 4667747..4667950 + 204 WP_000111289.1 hypothetical protein -
AOY57_RS23105 (4667943) 4667943..4668182 + 240 WP_000476211.1 hypothetical protein -
AOY57_RS23110 (4668179) 4668179..4668589 + 411 WP_201478761.1 ead/Ea22-like family protein -
AOY57_RS23115 (4668591) 4668591..4668870 + 280 Protein_4541 hypothetical protein -
AOY57_RS23120 (4668870) 4668870..4669442 + 573 WP_201478762.1 3'-5' exonuclease -
AOY57_RS23125 (4669479) 4669479..4669751 + 273 WP_001093911.1 pyocin activator PrtN family protein -
AOY57_RS23130 (4669785) 4669785..4670333 - 549 WP_000019185.1 hypothetical protein Toxin
AOY57_RS23135 (4670356) 4670356..4670829 - 474 WP_000287252.1 DUF4065 domain-containing protein Antitoxin
AOY57_RS23140 (4671352) 4671352..4671867 + 516 WP_000416264.1 zinc uptake transcriptional repressor Zur -
AOY57_RS23145 (4671909) 4671909..4672118 - 210 WP_001296638.1 CsbD family protein -
AOY57_RS23150 (4672234) 4672234..4673559 - 1326 WP_001296637.1 MATE family efflux transporter DinF -
AOY57_RS23155 (4673632) 4673632..4674240 - 609 WP_000646078.1 transcriptional repressor LexA -
AOY57_RS23160 (4674350) 4674350..4674718 - 369 WP_000002899.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4620373..4674240 53867


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-123)


Sequences

Toxin        


Download         Length: 183 a.a.        Molecular weight: 19920.31 Da        Isoelectric Point: 4.5029

>T104006 WP_000019185.1 NZ_CP028768:c4670333-4669785 [Escherichia coli]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQAFESAFEPSNHERDDDSSSENKAILEAEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVAGMFVSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDGDKEK

Download         Length: 549 bp

>T104006 NZ_CP028768:c4670333-4669785 [Escherichia coli]
ATGTCTCATAATTCAGATATCTATAAACTGATCGGAGCGGCCGCAGGTGTTGAAAATGGTCGCTCTGAAGCATCCTTAAA
CTCTACTGACAGTCAAGAGCAGGCTTTTGAATCCGCATTTGAGCCGTCTAATCATGAGCGCGATGATGATTCTTCTTCCG
AAAATAAGGCTATTCTGGAGGCAGAAGAGTTTGGTTCTAATACTGGTGCATTGCATGAGTTTATGCAGCAGAACAGAATG
GACAGTCTTCAAGCTCAGCTTGATATGCTCAAGTCACAAGTACGGGATAAGATAGCTGACGCAACTGGTAAAGAAATAGA
CAATGAGCTTCGGACAAAAATGGCCTCATTCACGGTTTGGTTTATGTCGTGTTGGTGCTTATTTGTAGCCGGAATGTTTG
TATCATTTCTTATTGCTCATGAAGGAAAGCCGCCAGTTGAAGCAATCGTTGCATTACTGGGAACAAGTACAATTAGTATT
GTTGGTTTGGTTGGCTTCGTTGTTAGTGGATTGTTCAAATCTAGAAAAGATGGCGATAAAGAAAAATAA

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17298.80 Da        Isoelectric Point: 8.4143

>AT104006 WP_000287252.1 NZ_CP028768:c4670829-4670356 [Escherichia coli]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL

Download         Length: 474 bp

>AT104006 NZ_CP028768:c4670829-4670356 [Escherichia coli]
ATGTACAGTCCGGTACAAATAGCCAATAAATTCATAACGTTGGGAAACCAACATCATAATCCTCTGACCCACATGCAACT
GCAGAAGCTTACTTATATTGCCCATGGTTACTATTTAGCATTAACAGGTAAGCCTTTGCTCAATGAATGTGTCTCCGCGT
GGAAGTACGGTCCAGTTATTCCTGGAATGTACGATGCTTTCAAAGACTATGGGAATAAACCTGTTACGAATGTAGCAGTA
GCTCCTTTTGGTGGCATCGTTACTATGGATCCGCAAGCAGAGAGCATTATAGGGGCCGTTTATAAGTTTTACGGTTCGAA
AAATGGAATTGAGTTATCAACTCTAACTCATATGCCAGGTACGCCTTGGTCACAAGCTTATAATGGTATTGGCTCGTCGA
TCATCTCAAATGATGCGATCAAGGCTTATTATCATGATTTATTGAATAACCGACAGCAATGTCAGGGCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K4KFL7

Antitoxin

Source ID Structure
AlphaFold DB A0A839B6W4

References