Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2462324..2462795 | Replicon | chromosome |
| Accession | NZ_CP028768 | ||
| Organism | Escherichia coli strain A6 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | AOY57_RS12060 | Protein ID | WP_001303511.1 |
| Coordinates | 2462324..2462602 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | - |
| Locus tag | AOY57_RS12065 | Protein ID | WP_201478561.1 |
| Coordinates | 2462604..2462795 (-) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AOY57_RS12020 (2458638) | 2458638..2458826 | - | 189 | WP_201478565.1 | DUF1482 family protein | - |
| AOY57_RS12025 (2458823) | 2458823..2459011 | - | 189 | WP_201478564.1 | cell division inhibition protein DicB | - |
| AOY57_RS12030 (2459022) | 2459022..2459876 | - | 855 | WP_201478563.1 | Rha family phage regulatory protein | - |
| AOY57_RS12035 (2460425) | 2460425..2460940 | + | 516 | WP_201478601.1 | hypothetical protein | - |
| AOY57_RS12040 (2461059) | 2461059..2461343 | + | 285 | WP_074464356.1 | type V toxin-antitoxin system endoribonuclease antitoxin GhoS | - |
| AOY57_RS12045 (2461361) | 2461361..2461486 | - | 126 | Protein_2363 | hypothetical protein | - |
| AOY57_RS12050 (2461493) | 2461493..2461717 | - | 225 | WP_201478562.1 | hypothetical protein | - |
| AOY57_RS24870 (2461747) | 2461747..2461875 | - | 129 | WP_274540486.1 | protein YdfB | - |
| AOY57_RS12055 (2461877) | 2461877..2462032 | - | 156 | WP_000379560.1 | DUF1391 family protein | - |
| AOY57_RS12060 (2462324) | 2462324..2462602 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| AOY57_RS12065 (2462604) | 2462604..2462795 | - | 192 | WP_201478561.1 | stability determinant | Antitoxin |
| AOY57_RS12070 (2462816) | 2462816..2463187 | - | 372 | WP_201478560.1 | hypothetical protein | - |
| AOY57_RS12075 (2463285) | 2463285..2463587 | + | 303 | WP_109552861.1 | transcriptional regulator | - |
| AOY57_RS12080 (2463584) | 2463584..2464009 | + | 426 | WP_201478559.1 | toxin YdaT family protein | - |
| AOY57_RS12085 (2464080) | 2464080..2465093 | + | 1014 | WP_201478558.1 | DUF1376 domain-containing protein | - |
| AOY57_RS12090 (2465086) | 2465086..2465547 | + | 462 | WP_240726666.1 | replication protein P | - |
| AOY57_RS12095 (2465582) | 2465582..2466292 | + | 711 | WP_201478556.1 | DUF1627 domain-containing protein | - |
| AOY57_RS12100 (2466358) | 2466358..2466612 | + | 255 | WP_240726667.1 | DNA-binding protein | - |
| AOY57_RS12105 (2466609) | 2466609..2466920 | + | 312 | Protein_2376 | DUF4406 domain-containing protein | - |
| AOY57_RS12110 (2466917) | 2466917..2467135 | + | 219 | WP_201478555.1 | DUF4014 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2442734..2506402 | 63668 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T103998 WP_001303511.1 NZ_CP028768:c2462602-2462324 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T103998 NZ_CP028768:c2462602-2462324 [Escherichia coli]
ATGTTACCCGTATTATGGCTTGAAAGCGCAGATACCGACCTGGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCAGAACGCTTATGGCAACGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACACCCGTATTTATACCCACCAAGCG
ACAGGGTGCCTGGCTTGCGTGAGATTGTGGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTATTATGGCTTGAAAGCGCAGATACCGACCTGGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCAGAACGCTTATGGCAACGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACACCCGTATTTATACCCACCAAGCG
ACAGGGTGCCTGGCTTGCGTGAGATTGTGGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7391.41 Da Isoelectric Point: 9.9931
>AT103998 WP_201478561.1 NZ_CP028768:c2462795-2462604 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAGRFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAGRFAKMRKERSKQ
Download Length: 192 bp
>AT103998 NZ_CP028768:c2462795-2462604 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAGTTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCTCATGACGAAGTTGAACGCAGAATGGCAGGACGCTTTG
CTAAAATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAGTTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCTCATGACGAAGTTGAACGCAGAATGGCAGGACGCTTTG
CTAAAATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|