Detailed information of TA system TA103982

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4006457..4007292
• Replicon: chromosome
• Accession: NZ_CP028767
• Organism: Escherichia coli strain A7

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: AOY58_RS19025
• Protein ID: WP_097344032.1
• Coordinates: 4006915..4007292 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: AOY58_RS19020
• Protein ID: WP_024174331.1
• Coordinates: 4006457..4006825 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AOY58_RS18995 (4002800)	4002800..4003977	+	1178	WP_085968792.1	IS3 family transposase	-
AOY58_RS19000 (4004206)	4004206..4005024	+	819	WP_001234381.1	DUF932 domain-containing protein	-
AOY58_RS19005 (4005116)	4005116..4005601	+	486	WP_000214415.1	antirestriction protein	-
AOY58_RS19010 (4005617)	4005617..4006093	+	477	WP_001186725.1	RadC family protein	-
AOY58_RS19015 (4006162)	4006162..4006383	+	222	WP_000692346.1	DUF987 domain-containing protein	-
AOY58_RS19020 (4006457)	4006457..4006825	+	369	WP_024174331.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
AOY58_RS19025 (4006915)	4006915..4007292	+	378	WP_097344032.1	TA system toxin CbtA family protein	Toxin
AOY58_RS19030 (4007289)	4007289..4007777	+	489	WP_000761717.1	DUF5983 family protein	-
AOY58_RS19035 (4007789)	4007789..4007986	+	198	WP_000838536.1	DUF957 domain-containing protein	-
AOY58_RS19040 (4008071)	4008071..4008913	+	843	WP_001280499.1	DUF4942 domain-containing protein	-
AOY58_RS19045 (4009194)	4009194..4009730	-	537	WP_000942799.1	GspM family type II secretion system protein YghD	-
AOY58_RS19050 (4009732)	4009732..4010910	-	1179	WP_000094973.1	type II secretion system protein GspL	-
AOY58_RS19055 (4010907)	4010907..4011884	-	978	WP_000633236.1	type II secretion system minor pseudopilin GspK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14224.13 Da
• Isoelectric Point: 6.8518

>T103982 WP_097344032.1 NZ_CP028767:4006915-4007292 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFTDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRMVNNITQGKHPEAQQ

Nucleotide

• Length: 378 bp

>T103982 NZ_CP028767:4006915-4007292 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCACCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTACGAACTGACCAGCCAGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAATGGTAAATAACATTACCCAGGGTAAGCATCCGGAGGCGCAACAATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13603.42 Da
• Isoelectric Point: 6.7386

>AT103982 WP_024174331.1 NZ_CP028767:4006457-4006825 [Escherichia coli]
VSDTLPGTTHPDDNHDRLWWGLPCTVTPCFGARLVQKGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKT

Nucleotide

• Length: 369 bp

>AT103982 NZ_CP028767:4006457-4006825 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGAAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAACGTAA