Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1962177..1963021 Replicon chromosome
Accession NZ_CP028767
Organism Escherichia coli strain A7

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag AOY58_RS09155 Protein ID WP_000854686.1
Coordinates 1962638..1963021 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag AOY58_RS09150 Protein ID WP_097343870.1
Coordinates 1962177..1962557 (+) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY58_RS09115 (1958427) 1958427..1958881 + 455 Protein_1766 IrmA family protein -
AOY58_RS09120 (1958960) 1958960..1959193 + 234 WP_001119719.1 DUF905 family protein -
AOY58_RS09125 (1959293) 1959293..1960111 + 819 WP_097343872.1 DUF932 domain-containing protein -
AOY58_RS09130 (1960203) 1960203..1960688 + 486 WP_001697217.1 antirestriction protein -
AOY58_RS09135 (1960704) 1960704..1961180 + 477 WP_001186726.1 RadC family protein -
AOY58_RS09140 (1961243) 1961243..1961464 + 222 WP_097343871.1 DUF987 domain-containing protein -
AOY58_RS09145 (1961483) 1961483..1962166 + 684 WP_001696891.1 hypothetical protein -
AOY58_RS09150 (1962177) 1962177..1962557 + 381 WP_097343870.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AOY58_RS09155 (1962638) 1962638..1963021 + 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
AOY58_RS09160 (1963018) 1963018..1963506 + 489 WP_001054233.1 DUF5983 family protein -
AOY58_RS09165 (1963523) 1963523..1963720 + 198 WP_000839253.1 DUF957 domain-containing protein -
AOY58_RS09170 (1963805) 1963805..1964647 + 843 WP_021513039.1 DUF4942 domain-containing protein -
AOY58_RS09180 (1965118) 1965118..1966056 + 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
AOY58_RS09185 (1966111) 1966111..1966848 + 738 WP_000283664.1 zinc-binding phosphatase -
AOY58_RS09190 (1966872) 1966872..1967426 + 555 WP_001001902.1 molecular chaperone YcdY -
AOY58_RS09195 (1967528) 1967528..1968019 + 492 WP_001297187.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T103962 WP_000854686.1 NZ_CP028767:1962638-1963021 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T103962 NZ_CP028767:1962638-1963021 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13937.75 Da        Isoelectric Point: 6.0618

>AT103962 WP_097343870.1 NZ_CP028767:1962177-1962557 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATKTESNPPE

Download         Length: 381 bp

>AT103962 NZ_CP028767:1962177-1962557 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCAAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References