Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1232604..1233222 Replicon chromosome
Accession NZ_CP028767
Organism Escherichia coli strain A7

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag AOY58_RS05715 Protein ID WP_001291435.1
Coordinates 1232604..1232822 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag AOY58_RS05720 Protein ID WP_000344800.1
Coordinates 1232848..1233222 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY58_RS05680 (1227894) 1227894..1228466 + 573 WP_000779826.1 YbaY family lipoprotein -
AOY58_RS05685 (1228497) 1228497..1228808 - 312 WP_000409911.1 MGMT family protein -
AOY58_RS05695 (1229187) 1229187..1229540 + 354 WP_000878141.1 DUF1428 family protein -
AOY58_RS05700 (1229582) 1229582..1231132 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
AOY58_RS05705 (1231296) 1231296..1231766 - 471 WP_000136192.1 YlaC family protein -
AOY58_RS05710 (1231882) 1231882..1232433 - 552 WP_000102564.1 maltose O-acetyltransferase -
AOY58_RS05715 (1232604) 1232604..1232822 - 219 WP_001291435.1 HHA domain-containing protein Toxin
AOY58_RS05720 (1232848) 1232848..1233222 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
AOY58_RS05725 (1233768) 1233768..1236917 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
AOY58_RS05730 (1236940) 1236940..1238133 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T103961 WP_001291435.1 NZ_CP028767:c1232822-1232604 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T103961 NZ_CP028767:c1232822-1232604 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT103961 WP_000344800.1 NZ_CP028767:c1233222-1232848 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT103961 NZ_CP028767:c1233222-1232848 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References