103951

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3605878..3606503 Replicon chromosome
Accession NZ_CP028766
Organism Escherichia coli strain A8

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag AOY61_RS17580 Protein ID WP_000911329.1
Coordinates 3605878..3606276 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag AOY61_RS17585 Protein ID WP_000450524.1
Coordinates 3606276..3606503 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY61_RS17560 (3601756) 3601756..3601956 + 201 WP_000383836.1 YpfN family protein -
AOY61_RS17565 (3602066) 3602066..3602764 - 699 WP_000679823.1 esterase -
AOY61_RS17570 (3602838) 3602838..3604853 - 2016 WP_000829294.1 tRNA cytosine(34) acetyltransferase TmcA -
AOY61_RS17575 (3604868) 3604868..3605731 - 864 WP_001267498.1 neutral zinc metallopeptidase -
AOY61_RS17580 (3605878) 3605878..3606276 - 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
AOY61_RS17585 (3606276) 3606276..3606503 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
AOY61_RS17590 (3606658) 3606658..3607371 - 714 WP_096979060.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
AOY61_RS17595 (3607584) 3607584..3608618 - 1035 WP_001440783.1 outer membrane protein assembly factor BamC -
AOY61_RS17600 (3608635) 3608635..3609513 - 879 WP_096979059.1 4-hydroxy-tetrahydrodipicolinate synthase -
AOY61_RS17605 (3609659) 3609659..3610231 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
AOY61_RS17610 (3610231) 3610231..3610701 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T103951 WP_000911329.1 NZ_CP028766:c3606276-3605878 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T103951 NZ_CP028766:c3606276-3605878 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACT
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT103951 WP_000450524.1 NZ_CP028766:c3606503-3606276 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT103951 NZ_CP028766:c3606503-3606276 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGATGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References