Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2637084..2637562 | Replicon | chromosome |
| Accession | NZ_CP028766 | ||
| Organism | Escherichia coli strain A8 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | - |
| Locus tag | AOY61_RS12890 | Protein ID | WP_089643319.1 |
| Coordinates | 2637275..2637562 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | - |
| Locus tag | AOY61_RS12885 | Protein ID | WP_096979221.1 |
| Coordinates | 2637084..2637275 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AOY61_RS12835 (2632546) | 2632546..2632911 | - | 366 | WP_096979208.1 | HNH endonuclease signature motif containing protein | - |
| AOY61_RS12840 (2632913) | 2632913..2633131 | - | 219 | WP_096979210.1 | DUF4014 family protein | - |
| AOY61_RS12845 (2633133) | 2633133..2633609 | - | 477 | WP_240774763.1 | hypothetical protein | - |
| AOY61_RS12850 (2633707) | 2633707..2634063 | - | 357 | WP_096979213.1 | hypothetical protein | - |
| AOY61_RS12855 (2634121) | 2634121..2634543 | - | 423 | WP_023234156.1 | DUF977 family protein | - |
| AOY61_RS12860 (2634584) | 2634584..2635549 | - | 966 | WP_096979215.1 | hypothetical protein | - |
| AOY61_RS12865 (2635546) | 2635546..2635839 | - | 294 | WP_024233241.1 | hypothetical protein | - |
| AOY61_RS12870 (2635861) | 2635861..2636286 | - | 426 | WP_096979217.1 | toxin YdaT family protein | - |
| AOY61_RS12875 (2636270) | 2636270..2636542 | - | 273 | WP_096979219.1 | YdaS family helix-turn-helix protein | - |
| AOY61_RS12880 (2636652) | 2636652..2637053 | + | 402 | WP_001329851.1 | helix-turn-helix domain-containing protein | - |
| AOY61_RS12885 (2637084) | 2637084..2637275 | + | 192 | WP_096979221.1 | antitoxin | Antitoxin |
| AOY61_RS12890 (2637275) | 2637275..2637562 | + | 288 | WP_089643319.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| AOY61_RS12895 (2637839) | 2637839..2637994 | + | 156 | WP_000379575.1 | DUF1391 family protein | - |
| AOY61_RS24400 (2637996) | 2637996..2638124 | + | 129 | WP_096979223.1 | hypothetical protein | - |
| AOY61_RS12900 (2638155) | 2638155..2638370 | + | 216 | WP_096979225.1 | hypothetical protein | - |
| AOY61_RS12905 (2638386) | 2638386..2638505 | + | 120 | Protein_2515 | hypothetical protein | - |
| AOY61_RS12910 (2638537) | 2638537..2638761 | - | 225 | WP_032083264.1 | hypothetical protein | - |
| AOY61_RS12915 (2639323) | 2639323..2639511 | + | 189 | WP_042974855.1 | cell division inhibition protein DicB | - |
| AOY61_RS12920 (2639508) | 2639508..2639711 | + | 204 | WP_001090252.1 | DUF1482 family protein | - |
| AOY61_RS12925 (2639791) | 2639791..2642265 | + | 2475 | WP_201475702.1 | exonuclease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2600641..2644031 | 43390 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10919.81 Da Isoelectric Point: 10.1360
>T103941 WP_089643319.1 NZ_CP028766:2637275-2637562 [Escherichia coli]
MLPILWLPSARDDLRQIVAYIAKENIPAARRLKIRIETSVLALSEHPYLYPPSDRVSGLREIVVHPNYIVLYRVATSSIE
IANIVHARRQFPFSI
MLPILWLPSARDDLRQIVAYIAKENIPAARRLKIRIETSVLALSEHPYLYPPSDRVSGLREIVVHPNYIVLYRVATSSIE
IANIVHARRQFPFSI
Download Length: 288 bp
>T103941 NZ_CP028766:2637275-2637562 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCATCTGCTCGCGATGATTTACGTCAGATCGTAGCCTATATTGCCAAGGAAAATATTCC
TGCAGCACGCAGACTAAAAATACGTATTGAAACGTCTGTTTTAGCCCTTTCTGAGCACCCATATCTATATCCGCCAAGTG
ATCGAGTATCCGGTTTGCGGGAAATTGTGGTTCACCCTAATTATATCGTTTTGTACCGAGTAGCAACTTCAAGTATTGAA
ATTGCAAATATTGTGCACGCCCGCCGACAATTTCCCTTCTCTATCTGA
ATGTTACCCATTTTATGGCTACCATCTGCTCGCGATGATTTACGTCAGATCGTAGCCTATATTGCCAAGGAAAATATTCC
TGCAGCACGCAGACTAAAAATACGTATTGAAACGTCTGTTTTAGCCCTTTCTGAGCACCCATATCTATATCCGCCAAGTG
ATCGAGTATCCGGTTTGCGGGAAATTGTGGTTCACCCTAATTATATCGTTTTGTACCGAGTAGCAACTTCAAGTATTGAA
ATTGCAAATATTGTGCACGCCCGCCGACAATTTCCCTTCTCTATCTGA
Antitoxin
Download Length: 64 a.a. Molecular weight: 6971.74 Da Isoelectric Point: 4.0270
>AT103941 WP_096979221.1 NZ_CP028766:2637084-2637275 [Escherichia coli]
MSTALSPIVSEFETTEQENSYNEWLRAKVASGLADPRPAIPHDEVMAEIENLIAQIAVTNRSE
MSTALSPIVSEFETTEQENSYNEWLRAKVASGLADPRPAIPHDEVMAEIENLIAQIAVTNRSE
Download Length: 192 bp
>AT103941 NZ_CP028766:2637084-2637275 [Escherichia coli]
ATGAGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGCTGCGCGC
TAAAGTGGCGTCAGGCCTTGCAGACCCTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATAGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAGGAGCGAGTAA
ATGAGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGCTGCGCGC
TAAAGTGGCGTCAGGCCTTGCAGACCCTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATAGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAGGAGCGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|