Detailed information of TA system TA103939

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 2100728..2101206
• Replicon: chromosome
• Accession: NZ_CP028766
• Organism: Escherichia coli strain A8

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: -
• Locus tag: AOY61_RS10055
• Protein ID: WP_096979146.1
• Coordinates: 2100728..2101015 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: -
• Locus tag: AOY61_RS10060
• Protein ID: WP_096979147.1
• Coordinates: 2101015..2101206 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AOY61_RS10030 (2095734)	2095734..2098205	-	2472	WP_096979143.1	exonuclease	-
AOY61_RS10035 (2098326)	2098326..2098547	-	222	WP_033552884.1	cell division protein FtsZ	-
AOY61_RS10040 (2098593)	2098593..2099441	-	849	WP_096979144.1	Rha family phage regulatory protein	-
AOY61_RS10045 (2099983)	2099983..2100240	+	258	WP_073568656.1	hypothetical protein	-
AOY61_RS10050 (2100194)	2100194..2100451	-	258	WP_174144317.1	hypothetical protein	-
AOY61_RS10055 (2100728)	2100728..2101015	-	288	WP_096979146.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AOY61_RS10060 (2101015)	2101015..2101206	-	192	WP_096979147.1	antitoxin	Antitoxin
AOY61_RS10065 (2101232)	2101232..2101633	-	402	WP_001329851.1	helix-turn-helix domain-containing protein	-
AOY61_RS10070 (2101743)	2101743..2102016	+	274	Protein_1954	YdaS family helix-turn-helix protein	-
AOY61_RS10075 (2102000)	2102000..2102425	+	426	WP_000693850.1	toxin YdaT family protein	-
AOY61_RS10080 (2102497)	2102497..2103567	+	1071	WP_096979148.1	phage replisome organizer	-
AOY61_RS10085 (2103608)	2103608..2104030	+	423	WP_096979149.1	DUF977 family protein	-
AOY61_RS10090 (2104088)	2104088..2104444	+	357	WP_201475696.1	hypothetical protein	-
AOY61_RS10095 (2104496)	2104496..2104708	+	213	WP_086522857.1	hypothetical protein	-
AOY61_RS10100 (2104744)	2104744..2105163	+	420	WP_096979703.1	hypothetical protein	-
AOY61_RS10105 (2105523)	2105523..2105888	+	366	WP_096979699.1	HNH endonuclease signature motif containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2085921..2194334	108413

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10843.72 Da
• Isoelectric Point: 10.1360

>T103939 WP_096979146.1 NZ_CP028766:c2101015-2100728 [Escherichia coli]
MLPILWLPSARDDLRQIVAYIAKENVPAARRLKIRIETSVLALSEHPYLYPPSDRVSGLREIVAHPNYIVLYRVAASSIE
IVNIVHARRQFPFPA

Nucleotide

• Length: 288 bp

>T103939 NZ_CP028766:c2101015-2100728 [Escherichia coli]
ATGCTACCCATTTTATGGCTACCATCTGCTCGCGATGATTTGCGTCAGATCGTAGCCTATATTGCCAAGGAAAATGTTCC
AGCAGCTCGTAGACTAAAAATACGTATTGAAACGTCTGTTTTAGCCCTCTCAGAGCATCCATATCTATATCCGCCAAGTG
ATAGAGTATCCGGTTTGCGGGAAATTGTAGCTCACCCTAATTATATCGTTTTGTACCGAGTAGCAGCTTCAAGCATTGAA
ATTGTAAATATTGTGCATGCCCGCAGACAGTTCCCCTTCCCTGCCTGA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 6835.60 Da
• Isoelectric Point: 3.9389

>AT103939 WP_096979147.1 NZ_CP028766:c2101206-2101015 [Escherichia coli]
MSTALSPIVSEFETTEQENSYNEWLRAKVASSLADPRPAIPHDEVMAEMENLIAQIAATSGSV

Nucleotide

• Length: 192 bp

>AT103939 NZ_CP028766:c2101206-2101015 [Escherichia coli]
ATGAGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCGC
TAAAGTCGCGTCAAGCCTTGCAGATCCTCGCCCCGCAATACCGCATGACGAGGTGATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGCGACTAGCGGGAGTGTGTAA