103938

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1292867..1293485 Replicon chromosome
Accession NZ_CP028766
Organism Escherichia coli strain A8

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag AOY61_RS06100 Protein ID WP_001291435.1
Coordinates 1292867..1293085 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag AOY61_RS06105 Protein ID WP_000344800.1
Coordinates 1293111..1293485 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY61_RS06065 (1288157) 1288157..1288729 + 573 WP_000779831.1 YbaY family lipoprotein -
AOY61_RS06070 (1288760) 1288760..1289071 - 312 WP_000409911.1 MGMT family protein -
AOY61_RS06080 (1289450) 1289450..1289803 + 354 WP_000878140.1 DUF1428 domain-containing protein -
AOY61_RS06085 (1289845) 1289845..1291395 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
AOY61_RS06090 (1291559) 1291559..1292029 - 471 WP_000136192.1 YlaC family protein -
AOY61_RS06095 (1292145) 1292145..1292696 - 552 WP_000102564.1 maltose O-acetyltransferase -
AOY61_RS06100 (1292867) 1292867..1293085 - 219 WP_001291435.1 HHA domain-containing protein Toxin
AOY61_RS06105 (1293111) 1293111..1293485 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
AOY61_RS06110 (1294031) 1294031..1297180 - 3150 WP_096979107.1 efflux RND transporter permease AcrB -
AOY61_RS06115 (1297203) 1297203..1298396 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T103938 WP_001291435.1 NZ_CP028766:c1293085-1292867 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T103938 NZ_CP028766:c1293085-1292867 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT103938 WP_000344800.1 NZ_CP028766:c1293485-1293111 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT103938 NZ_CP028766:c1293485-1293111 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References