Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2299842..2300368 | Replicon | chromosome |
| Accession | NZ_CP028763 | ||
| Organism | Escherichia coli strain A11 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | AOY64_RS11030 | Protein ID | WP_000323025.1 |
| Coordinates | 2300081..2300368 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | AOY64_RS11025 | Protein ID | WP_000534858.1 |
| Coordinates | 2299842..2300081 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AOY64_RS10985 (2295025) | 2295025..2295255 | + | 231 | WP_000920568.1 | dicB transcriptional regulator DicC | - |
| AOY64_RS10990 (2295239) | 2295239..2295760 | + | 522 | WP_021531325.1 | toxin YdaT family protein | - |
| AOY64_RS10995 (2295741) | 2295741..2296706 | + | 966 | WP_123055762.1 | hypothetical protein | - |
| AOY64_RS11000 (2296747) | 2296747..2297166 | + | 420 | Protein_2157 | DUF977 family protein | - |
| AOY64_RS11005 (2297221) | 2297221..2298318 | + | 1098 | Protein_2158 | ISNCY family transposase | - |
| AOY64_RS11010 (2298391) | 2298391..2298540 | + | 150 | WP_180302674.1 | protein YdfW | - |
| AOY64_RS11015 (2298977) | 2298977..2299309 | - | 333 | WP_001317460.1 | FlxA-like family protein | - |
| AOY64_RS11020 (2299512) | 2299512..2299817 | - | 306 | WP_071527819.1 | protein YdfV | - |
| AOY64_RS11025 (2299842) | 2299842..2300081 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| AOY64_RS11030 (2300081) | 2300081..2300368 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| AOY64_RS11035 (2300440) | 2300440..2300595 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| AOY64_RS11040 (2300812) | 2300812..2301063 | + | 252 | WP_000980994.1 | protein Rem | - |
| AOY64_RS11045 (2301130) | 2301130..2301408 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| AOY64_RS11050 (2301410) | 2301410..2302459 | + | 1050 | WP_033815601.1 | DUF968 domain-containing protein | - |
| AOY64_RS11055 (2302473) | 2302473..2303225 | + | 753 | WP_001047135.1 | antitermination protein | - |
| AOY64_RS11060 (2303503) | 2303503..2303592 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| AOY64_RS11065 (2303647) | 2303647..2303859 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| AOY64_RS11070 (2304160) | 2304160..2304375 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| AOY64_RS11075 (2304739) | 2304739..2304909 | - | 171 | WP_212739912.1 | YnfU family zinc-binding protein | - |
| AOY64_RS11080 (2305129) | 2305129..2305344 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2283407..2335758 | 52351 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T103876 WP_000323025.1 NZ_CP028763:2300081-2300368 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T103876 NZ_CP028763:2300081-2300368 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT103876 WP_000534858.1 NZ_CP028763:2299842-2300081 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT103876 NZ_CP028763:2299842-2300081 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|