Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2938598..2939429 Replicon chromosome
Accession NZ_CP028760
Organism Escherichia coli strain A14

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag AOY67_RS14465 Protein ID WP_000854814.1
Coordinates 2939055..2939429 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag AOY67_RS14460 Protein ID WP_001285585.1
Coordinates 2938598..2938966 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY67_RS14420 (2934069) 2934069..2934473 - 405 WP_001459868.1 zinc-ribbon domain-containing protein -
AOY67_RS14425 (2934659) 2934659..2935627 + 969 Protein_2811 IS110 family transposase -
AOY67_RS14430 (2935637) 2935637..2936029 - 393 WP_032186701.1 putative zinc ribbon protein -
AOY67_RS14435 (2936195) 2936195..2936764 - 570 WP_000221529.1 inovirus Gp2 family protein -
AOY67_RS14440 (2936940) 2936940..2937136 + 197 Protein_2814 hypothetical protein -
AOY67_RS14445 (2937440) 2937440..2937748 + 309 Protein_2815 antirestriction protein -
AOY67_RS14450 (2937764) 2937764..2938240 + 477 WP_001186773.1 RadC family protein -
AOY67_RS14455 (2938303) 2938303..2938524 + 222 WP_000692323.1 DUF987 domain-containing protein -
AOY67_RS14460 (2938598) 2938598..2938966 + 369 WP_001285585.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
AOY67_RS14465 (2939055) 2939055..2939429 + 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
AOY67_RS14470 (2939426) 2939426..2939620 + 195 WP_000988600.1 DUF5983 family protein -
AOY67_RS14475 (2939666) 2939666..2939746 + 81 Protein_2821 hypothetical protein -
AOY67_RS14480 (2940035) 2940035..2940163 - 129 Protein_2822 transposase domain-containing protein -
AOY67_RS14485 (2940283) 2940283..2940417 + 135 WP_001297944.1 EutP/PduV family microcompartment system protein -
AOY67_RS14490 (2940518) 2940518..2940847 - 330 WP_000450409.1 DUF496 family protein -
AOY67_RS14495 (2941019) 2941019..2942077 - 1059 WP_001200891.1 FUSC family protein -
AOY67_RS14500 (2942275) 2942275..2942748 - 474 WP_001105414.1 DNA gyrase inhibitor SbmC -
AOY67_RS14505 (2942867) 2942867..2944033 - 1167 WP_001442313.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T103800 WP_000854814.1 NZ_CP028760:2939055-2939429 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T103800 NZ_CP028760:2939055-2939429 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT103800 WP_001285585.1 NZ_CP028760:2938598-2938966 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT103800 NZ_CP028760:2938598-2938966 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References