Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2458244..2458770 | Replicon | chromosome |
| Accession | NZ_CP028760 | ||
| Organism | Escherichia coli strain A14 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | AOY67_RS12070 | Protein ID | WP_000323025.1 |
| Coordinates | 2458244..2458531 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | AOY67_RS12075 | Protein ID | WP_000534858.1 |
| Coordinates | 2458531..2458770 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AOY67_RS12020 (2453268) | 2453268..2453483 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| AOY67_RS12025 (2453703) | 2453703..2453873 | + | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| AOY67_RS12030 (2454237) | 2454237..2454452 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| AOY67_RS12035 (2454753) | 2454753..2454965 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| AOY67_RS12040 (2455020) | 2455020..2455109 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| AOY67_RS12045 (2455387) | 2455387..2456139 | - | 753 | WP_001047135.1 | antitermination protein | - |
| AOY67_RS12050 (2456153) | 2456153..2457202 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| AOY67_RS12055 (2457204) | 2457204..2457482 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| AOY67_RS12060 (2457549) | 2457549..2457800 | - | 252 | WP_000980994.1 | protein Rem | - |
| AOY67_RS12065 (2458017) | 2458017..2458172 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| AOY67_RS12070 (2458244) | 2458244..2458531 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| AOY67_RS12075 (2458531) | 2458531..2458770 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| AOY67_RS12080 (2458795) | 2458795..2459100 | + | 306 | WP_001326990.1 | protein YdfV | - |
| AOY67_RS12085 (2459303) | 2459303..2459635 | + | 333 | WP_001301033.1 | FlxA-like family protein | - |
| AOY67_RS12090 (2460072) | 2460072..2460221 | - | 150 | WP_011443592.1 | protein YdfW | - |
| AOY67_RS12095 (2460294) | 2460294..2461364 | - | 1071 | Protein_2355 | ISNCY family transposase | - |
| AOY67_RS12100 (2462154) | 2462154..2462441 | - | 288 | Protein_2356 | hypothetical protein | - |
| AOY67_RS12105 (2462919) | 2462919..2463408 | - | 490 | Protein_2357 | class I SAM-dependent methyltransferase | - |
| AOY67_RS12110 (2463405) | 2463405..2463656 | - | 252 | Protein_2358 | DUF977 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2444278..2488119 | 43841 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T103791 WP_000323025.1 NZ_CP028760:c2458531-2458244 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T103791 NZ_CP028760:c2458531-2458244 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT103791 WP_000534858.1 NZ_CP028760:c2458770-2458531 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT103791 NZ_CP028760:c2458770-2458531 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|