Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 336475..337400 Replicon chromosome
Accession NZ_CP028760
Organism Escherichia coli strain A14

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag AOY67_RS01545 Protein ID WP_014640052.1
Coordinates 337014..337400 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag AOY67_RS01540 Protein ID WP_024174200.1
Coordinates 336475..336984 (+) Length 170 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY67_RS01510 (331500) 331500..332108 + 609 WP_000646078.1 transcriptional repressor LexA -
AOY67_RS01515 (332181) 332181..333506 + 1326 WP_001326646.1 MATE family efflux transporter DinF -
AOY67_RS01520 (333622) 333622..333831 + 210 WP_001030593.1 CsbD family protein -
AOY67_RS01525 (333873) 333873..334388 - 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
AOY67_RS23300 (334706) 334706..334960 + 255 WP_000912571.1 protein YjbL -
AOY67_RS01530 (334984) 334984..335691 + 708 WP_001311303.1 DUF2713 domain-containing protein -
AOY67_RS01535 (336054) 336054..336158 + 105 Protein_281 tRNA-dihydrouridine synthase -
AOY67_RS01540 (336475) 336475..336984 + 510 WP_024174200.1 Panacea domain-containing protein Antitoxin
AOY67_RS01545 (337014) 337014..337400 + 387 WP_014640052.1 hypothetical protein Toxin
AOY67_RS01550 (337440) 337440..337613 + 174 WP_000390072.1 hypothetical protein -
AOY67_RS01555 (337661) 337661..337942 - 282 WP_001093916.1 pyocin activator PrtN family protein -
AOY67_RS01560 (337979) 337979..338761 - 783 WP_047654657.1 hypothetical protein -
AOY67_RS01565 (338950) 338950..339774 - 825 WP_000081311.1 DUF2303 family protein -
AOY67_RS01570 (339840) 339840..340202 - 363 WP_000135680.1 protein YfdP -
AOY67_RS01575 (340889) 340889..341563 - 675 WP_000859461.1 LexA family transcriptional regulator -
AOY67_RS01580 (341654) 341654..341854 + 201 WP_000649477.1 YdaS family helix-turn-helix protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 331500..384547 53047


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(6-116)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T103778 WP_014640052.1 NZ_CP028760:337014-337400 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

>T103778 NZ_CP028760:337014-337400 [Escherichia coli]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTCTTGAATTCTGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCCGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATATCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin


Download         Length: 170 a.a.        Molecular weight: 19559.39 Da        Isoelectric Point: 5.3338

>AT103778 WP_024174200.1 NZ_CP028760:336475-336984 [Escherichia coli]
MAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHDVLLRSDPREMDAD
EVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Download         Length: 510 bp

>AT103778 NZ_CP028760:336475-336984 [Escherichia coli]
ATGGCATATCTGAAATTGATGAAGCTGCTCTATCTGTCTAACCGCAAGTCGATTTTGAAGCATGGCAGGATGATCGGCGA
AGATAGCCTTTACTCTATGAAATTTGGTCCAGTCATGTCGAATACGCTGAACTTGATTCGTGGTAAGGCTGAAGGTATTG
GTGACTACTGGTACAACCTGATAGAGACGAACGGGCATGATGTGTTGTTGCGTTCAGATCCGAGGGAAATGGATGCAGAC
GAGGTCTTTGATGAGTTGAGCCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCTGTATGGGCATATGAACCGATT
TGATCTCGCAAACATGACGCATTTAGAAAGCGTTTGTCCAGAGTGGCACAATCCTGGCAATTCTCGTAAGCCTATAGACC
TGAAAGAAATGCTGATCAGTGAGGGTAAAAGCGAGGATGAGGCTAATCGTATAATTGGCAAAATGGAAGAATCTCAGAAA
CTTAAGGAATTTTCTTTGCAATTATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References