Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1241201..1241819 Replicon chromosome
Accession NZ_CP028759
Organism Escherichia coli strain A15

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag AOY68_RS05735 Protein ID WP_001291435.1
Coordinates 1241201..1241419 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag AOY68_RS05740 Protein ID WP_000344800.1
Coordinates 1241445..1241819 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY68_RS05700 (1236491) 1236491..1237063 + 573 WP_000779826.1 YbaY family lipoprotein -
AOY68_RS05705 (1237094) 1237094..1237405 - 312 WP_000409911.1 MGMT family protein -
AOY68_RS05715 (1237784) 1237784..1238137 + 354 WP_000878140.1 DUF1428 domain-containing protein -
AOY68_RS05720 (1238179) 1238179..1239729 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
AOY68_RS05725 (1239893) 1239893..1240363 - 471 WP_000136192.1 YlaC family protein -
AOY68_RS05730 (1240479) 1240479..1241030 - 552 WP_000102564.1 maltose O-acetyltransferase -
AOY68_RS05735 (1241201) 1241201..1241419 - 219 WP_001291435.1 HHA domain-containing protein Toxin
AOY68_RS05740 (1241445) 1241445..1241819 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
AOY68_RS05745 (1242365) 1242365..1245514 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
AOY68_RS05750 (1245537) 1245537..1246730 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T103762 WP_001291435.1 NZ_CP028759:c1241419-1241201 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T103762 NZ_CP028759:c1241419-1241201 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT103762 WP_000344800.1 NZ_CP028759:c1241819-1241445 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT103762 NZ_CP028759:c1241819-1241445 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References