Detailed information of TA system TA103686

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 831367..832168
• Replicon: chromosome
• Accession: NZ_CP028756
• Organism: Escherichia coli strain A19

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: AOY72_RS04015
• Protein ID: WP_201479300.1
• Coordinates: 831367..831744 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: AOY72_RS04020
• Protein ID: WP_201479301.1
• Coordinates: 831791..832168 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AOY72_RS03985 (826775)	826775..827752	+	978	WP_000633238.1	type II secretion system minor pseudopilin GspK	-
AOY72_RS03990 (827749)	827749..828927	+	1179	WP_000094962.1	type II secretion system protein GspL	-
AOY72_RS03995 (828929)	828929..829465	+	537	WP_000942795.1	GspM family type II secretion system protein YghD	-
AOY72_RS04000 (829746)	829746..830588	-	843	WP_201479297.1	DUF4942 domain-containing protein	-
AOY72_RS04005 (830673)	830673..830870	-	198	WP_201479298.1	hypothetical protein	-
AOY72_RS04010 (830882)	830882..831370	-	489	WP_201479299.1	DUF5983 family protein	-
AOY72_RS04015 (831367)	831367..831744	-	378	WP_201479300.1	TA system toxin CbtA family protein	Toxin
AOY72_RS04020 (831791)	831791..832168	-	378	WP_201479301.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
AOY72_RS04025 (832218)	832218..832862	-	645	WP_201479302.1	antitoxin of toxin-antitoxin stability system	-
AOY72_RS04030 (832881)	832881..833102	-	222	WP_201479303.1	DUF987 domain-containing protein	-
AOY72_RS04035 (833171)	833171..833647	-	477	WP_001186771.1	RadC family protein	-
AOY72_RS04040 (833663)	833663..834148	-	486	WP_201479304.1	antirestriction protein	-
AOY72_RS04045 (834240)	834240..835058	-	819	WP_201479305.1	DUF932 domain-containing protein	-
AOY72_RS04050 (835149)	835149..835382	-	234	WP_201479330.1	DUF905 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14087.06 Da
• Isoelectric Point: 7.3524

>T103686 WP_201479300.1 NZ_CP028756:c831744-831367 [Escherichia coli]
MKTLPDTHEREASRCPSPVTIWQTLLARLLGQHYSLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
GTCTHSQLINSIDILRARRATGLMTRDNYRTINDITLGKHPGVKQ

Nucleotide

• Length: 378 bp

>T103686 NZ_CP028756:c831744-831367 [Escherichia coli]
ATGAAAACATTACCCGACACACACGAACGGGAGGCGTCACGCTGCCCGTCTCCTGTGACAATCTGGCAGACACTCCTGGC
CCGGCTGCTGGGCCAGCATTACAGCCTCACGCTGAATGACACGCCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAGTACGCGCTGGTACGTACCGACCAGCCGGGATTC
GGCACCTGTACCCATTCGCAGTTAATAAACAGCATCGATATTCTCCGGGCTCGCCGGGCAACCGGCCTGATGACCCGCGA
CAACTACAGAACGATAAATGACATTACCTTGGGTAAACATCCGGGGGTGAAACAATGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 13765.42 Da
• Isoelectric Point: 6.1134

>AT103686 WP_201479301.1 NZ_CP028756:c832168-831791 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGQFSNADAYHLDQAFPLLLKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSWGYVYMAVYPTPAAPATTA

Nucleotide

• Length: 378 bp

>AT103686 NZ_CP028756:c832168-831791 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGATCGCGCAGGTATCAGAGGTCAGT
TCAGCAACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGCTGAAACAACTGGAGTTAATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
GGGTTACGTTTATATGGCTGTTTATCCGACACCGGCAGCTCCCGCAACAACCGCATAA