Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4623655..4624580 Replicon chromosome
Accession NZ_CP028755
Organism Escherichia coli strain A20

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag AOY73_RS22485 Protein ID WP_157915039.1
Coordinates 4623655..4624041 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag AOY73_RS22490 Protein ID WP_024174200.1
Coordinates 4624071..4624580 (-) Length 170 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY73_RS22435 (4619378) 4619378..4619914 + 537 WP_001401560.1 5'-deoxynucleotidase -
AOY73_RS22440 (4619905) 4619905..4620267 + 363 WP_024166531.1 hypothetical protein -
AOY73_RS22445 (4620264) 4620264..4620467 + 204 WP_000111289.1 hypothetical protein -
AOY73_RS22450 (4620460) 4620460..4620699 + 240 WP_000476211.1 hypothetical protein -
AOY73_RS22455 (4620696) 4620696..4621421 + 726 WP_047611180.1 ead/Ea22-like family protein -
AOY73_RS22460 (4621423) 4621423..4621614 + 192 WP_016236813.1 hypothetical protein -
AOY73_RS22465 (4621617) 4621617..4622504 + 888 WP_096980295.1 DUF551 domain-containing protein -
AOY73_RS22470 (4622504) 4622504..4623076 + 573 WP_001061345.1 3'-5' exonuclease -
AOY73_RS22475 (4623113) 4623113..4623394 + 282 WP_001093917.1 pyocin activator PrtN family protein -
AOY73_RS22480 (4623442) 4623442..4623615 - 174 WP_000390072.1 hypothetical protein -
AOY73_RS22485 (4623655) 4623655..4624041 - 387 WP_157915039.1 hypothetical protein Toxin
AOY73_RS22490 (4624071) 4624071..4624580 - 510 WP_024174200.1 Panacea domain-containing protein Antitoxin
AOY73_RS22495 (4625115) 4625115..4625630 + 516 WP_000416264.1 zinc uptake transcriptional repressor Zur -
AOY73_RS22500 (4625672) 4625672..4625881 - 210 WP_001296638.1 CsbD family protein -
AOY73_RS22505 (4625997) 4625997..4627322 - 1326 WP_001298291.1 MATE family efflux transporter DinF -
AOY73_RS22510 (4627395) 4627395..4628003 - 609 WP_000646078.1 transcriptional repressor LexA -
AOY73_RS22515 (4628113) 4628113..4628481 - 369 WP_000002899.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4555062..4628003 72941


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(6-116)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14483.43 Da        Isoelectric Point: 5.1062

>T103682 WP_157915039.1 NZ_CP028755:c4624041-4623655 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
QSCEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

>T103682 NZ_CP028755:c4624041-4623655 [Escherichia coli]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGGGTTCCCCACGATCCGTCTTGCGTCTTGAATTCAGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CAATCGTGTGAGATTTCTGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATATCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin


Download         Length: 170 a.a.        Molecular weight: 19559.39 Da        Isoelectric Point: 5.3338

>AT103682 WP_024174200.1 NZ_CP028755:c4624580-4624071 [Escherichia coli]
MAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHDVLLRSDPREMDAD
EVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Download         Length: 510 bp

>AT103682 NZ_CP028755:c4624580-4624071 [Escherichia coli]
ATGGCATATCTGAAATTGATGAAGCTGCTCTATCTGTCTAACCGCAAGTCGATTTTGAAGCATGGCAGGATGATCGGCGA
AGATAGCCTTTACTCTATGAAATTTGGTCCAGTCATGTCGAATACGCTGAACTTGATTCGTGGTAAGGCTGAAGGCATTG
GTGACTACTGGTACAACTTGATAGAGACGAACGGGCATGATGTGTTGTTGCGTTCAGATCCGAGGGAAATGGATGCAGAC
GAGGTCTTTGATGAGTTGAGCCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCTGTATGGGCATATGAACCGATT
TGATCTCGCAAACATGACGCATTTAGAAAGCGTTTGTCCAGAGTGGCACAATCCTGGCAATTCTCGTAAGCCTATAGACC
TGAAAGAAATGCTGATCAGTGAGGGTAAAAGCGAGGATGAGGCTAATCGCATAATTGGCAAAATGGAAGAATCTCAGAAA
CTTAAGGAATTTTCTTTGCAATTATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References