Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4267726..4268558 | Replicon | chromosome |
| Accession | NZ_CP028751 | ||
| Organism | Escherichia coli strain A24 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1PD64 |
| Locus tag | AOY77_RS20550 | Protein ID | WP_000854753.1 |
| Coordinates | 4268184..4268558 (+) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | AOY77_RS20545 | Protein ID | WP_001531802.1 |
| Coordinates | 4267726..4268094 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AOY77_RS20515 (4264560) | 4264560..4265015 | + | 456 | WP_000581502.1 | IrmA family protein | - |
| AOY77_RS20520 (4265158) | 4265158..4265247 | + | 90 | WP_112031555.1 | DUF905 family protein | - |
| AOY77_RS20525 (4265426) | 4265426..4266247 | + | 822 | WP_001531953.1 | DUF932 domain-containing protein | - |
| AOY77_RS20530 (4266302) | 4266302..4266787 | + | 486 | WP_201471951.1 | antirestriction protein | - |
| AOY77_RS20535 (4266803) | 4266803..4267279 | + | 477 | WP_001186726.1 | RadC family protein | - |
| AOY77_RS20540 (4267342) | 4267342..4267563 | + | 222 | WP_000692329.1 | DUF987 domain-containing protein | - |
| AOY77_RS20545 (4267726) | 4267726..4268094 | + | 369 | WP_001531802.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| AOY77_RS20550 (4268184) | 4268184..4268558 | + | 375 | WP_000854753.1 | TA system toxin CbtA family protein | Toxin |
| AOY77_RS20555 (4268555) | 4268555..4269043 | + | 489 | WP_000777541.1 | DUF5983 family protein | - |
| AOY77_RS20560 (4269055) | 4269055..4269252 | + | 198 | WP_000839281.1 | DUF957 domain-containing protein | - |
| AOY77_RS20565 (4269349) | 4269349..4269918 | + | 570 | WP_001290247.1 | DUF4942 domain-containing protein | - |
| AOY77_RS20570 (4270260) | 4270260..4270430 | + | 171 | Protein_4010 | IS110 family transposase | - |
| AOY77_RS20575 (4271240) | 4271240..4272223 | + | 984 | WP_001335608.1 | KpsF/GutQ family sugar-phosphate isomerase | - |
| AOY77_RS20580 (4272295) | 4272295..4273443 | + | 1149 | WP_000905914.1 | capsule polysaccharide transporter | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 4270326..4270430 | 104 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14005.00 Da Isoelectric Point: 8.2905
>T103580 WP_000854753.1 NZ_CP028751:4268184-4268558 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR
Download Length: 375 bp
>T103580 NZ_CP028751:4268184-4268558 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13422.27 Da Isoelectric Point: 6.3161
>AT103580 WP_001531802.1 NZ_CP028751:4267726-4268094 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNSLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNSLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
Download Length: 369 bp
>AT103580 NZ_CP028751:4267726-4268094 [Escherichia coli]
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACAGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACAGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|