Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3152190..3153021 Replicon chromosome
Accession NZ_CP028751
Organism Escherichia coli strain A24

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag AOY77_RS15450 Protein ID WP_000854814.1
Coordinates 3152647..3153021 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1PWQ3
Locus tag AOY77_RS15445 Protein ID WP_001285586.1
Coordinates 3152190..3152558 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY77_RS15410 (3147248) 3147248..3148318 + 1071 WP_000102631.1 patatin-like phospholipase family protein -
AOY77_RS15415 (3148454) 3148454..3149130 + 677 Protein_3001 hypothetical protein -
AOY77_RS15420 (3149146) 3149146..3149556 + 411 WP_000846704.1 hypothetical protein -
AOY77_RS15425 (3149777) 3149777..3150598 + 822 WP_001234571.1 DUF932 domain-containing protein -
AOY77_RS15430 (3150861) 3150861..3151334 + 474 WP_000855074.1 antirestriction protein -
AOY77_RS15435 (3151350) 3151350..3151826 + 477 WP_201472011.1 RadC family protein -
AOY77_RS15440 (3151895) 3151895..3152116 + 222 WP_000692323.1 DUF987 domain-containing protein -
AOY77_RS15445 (3152190) 3152190..3152558 + 369 WP_001285586.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
AOY77_RS15450 (3152647) 3152647..3153021 + 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
AOY77_RS15455 (3153018) 3153018..3153212 + 195 WP_000988601.1 DUF5983 family protein -
AOY77_RS15460 (3153258) 3153258..3153338 + 81 Protein_3010 hypothetical protein -
AOY77_RS15465 (3153627) 3153627..3153707 - 81 WP_023441679.1 hypothetical protein -
AOY77_RS15470 (3153686) 3153686..3154009 + 324 WP_223216378.1 EutP/PduV family microcompartment system protein -
AOY77_RS15475 (3154110) 3154110..3154439 - 330 WP_000450409.1 DUF496 family protein -
AOY77_RS15480 (3154611) 3154611..3155669 - 1059 WP_001200890.1 FUSC family protein -
AOY77_RS15485 (3155867) 3155867..3156340 - 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
AOY77_RS15490 (3156459) 3156459..3157625 - 1167 WP_001297905.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T103576 WP_000854814.1 NZ_CP028751:3152647-3153021 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T103576 NZ_CP028751:3152647-3153021 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.41 Da        Isoelectric Point: 5.0468

>AT103576 WP_001285586.1 NZ_CP028751:3152190-3152558 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT103576 NZ_CP028751:3152190-3152558 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB S1PWQ3

References