Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 530142..530973 Replicon chromosome
Accession NZ_CP028751
Organism Escherichia coli strain A24

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag AOY77_RS02565 Protein ID WP_021527014.1
Coordinates 530142..530519 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag AOY77_RS02570 Protein ID WP_201472244.1
Coordinates 530608..530973 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY77_RS02545 (526510) 526510..528048 - 1539 WP_001187191.1 lysine decarboxylation/transport transcriptional activator CadC -
AOY77_RS02550 (528796) 528796..529638 - 843 WP_054575888.1 DUF4942 domain-containing protein -
AOY77_RS02555 (529723) 529723..529920 - 198 WP_085975623.1 DUF957 domain-containing protein -
AOY77_RS02560 (529948) 529948..530145 - 198 Protein_481 DUF5983 family protein -
AOY77_RS02565 (530142) 530142..530519 - 378 WP_021527014.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
AOY77_RS02570 (530608) 530608..530973 - 366 WP_201472244.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
AOY77_RS02575 (531047) 531047..531268 - 222 WP_000692323.1 DUF987 domain-containing protein -
AOY77_RS02580 (531331) 531331..531807 - 477 WP_032261139.1 RadC family protein -
AOY77_RS02585 (531823) 531823..532308 - 486 WP_201472242.1 antirestriction protein -
AOY77_RS02590 (532400) 532400..533221 - 822 WP_201472241.1 DUF932 domain-containing protein -
AOY77_RS02595 (533311) 533311..533544 - 234 WP_001278287.1 DUF905 family protein -
AOY77_RS02600 (533550) 533550..534227 - 678 WP_040076088.1 hypothetical protein -
AOY77_RS02605 (534375) 534375..535055 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - hlyC / hlyA / hlyB / hlyD / cnf1 / papI / papB / papA / papH / papC / papD / papJ / papK / papE / papF / sfaY / papX 519021..622849 103828


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(17-116)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14010.13 Da        Isoelectric Point: 9.1378

>T103557 WP_021527014.1 NZ_CP028751:c530519-530142 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLGQHYGLTLDDTPFADERVIEQHIKAGISLCDAVNFLVEKYTLVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEVKR

Download         Length: 378 bp

>T103557 NZ_CP028751:c530519-530142 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
ACGGTTGCTGGGCCAGCATTACGGCCTTACGCTGGATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTA
AGGCAGGTATTTCACTGTGCGATGCAGTGAACTTTCTCGTTGAAAAATACACACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCACCCGGAGGTGAAACGATGA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13567.47 Da        Isoelectric Point: 7.2981

>AT103557 WP_201472244.1 NZ_CP028751:c530973-530608 [Escherichia coli]
VSDTLPGTTHPDNNNRPWWGLPCTVTPCFGARLVQEGNRLHYLADRACIRGRFSDADAYHLDQAFPLLMKQLELMLTSGE
LNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 366 bp

>AT103557 NZ_CP028751:c530973-530608 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACAACAACAACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGACGCC
CTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGTGCCTGTATCAGAGGGCGGTTCA
GCGATGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGTGAA
CTGAATCCCCGTCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTGTGG
TTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References