Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 362802..363727 Replicon chromosome
Accession NZ_CP028751
Organism Escherichia coli strain A24

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag AOY77_RS01680 Protein ID WP_014640052.1
Coordinates 363341..363727 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag AOY77_RS01675 Protein ID WP_001339382.1
Coordinates 362802..363311 (+) Length 170 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY77_RS01650 (358901) 358901..359269 + 369 WP_000002899.1 diacylglycerol kinase -
AOY77_RS01655 (359379) 359379..359987 + 609 WP_000646078.1 transcriptional repressor LexA -
AOY77_RS01660 (360060) 360060..361385 + 1326 WP_001298291.1 MATE family efflux transporter DinF -
AOY77_RS01665 (361501) 361501..361710 + 210 WP_001296638.1 CsbD family protein -
AOY77_RS01670 (361752) 361752..362267 - 516 WP_000416264.1 zinc uptake transcriptional repressor Zur -
AOY77_RS01675 (362802) 362802..363311 + 510 WP_001339382.1 Panacea domain-containing protein Antitoxin
AOY77_RS01680 (363341) 363341..363727 + 387 WP_014640052.1 hypothetical protein Toxin
AOY77_RS01685 (363767) 363767..363940 + 174 WP_021549909.1 hypothetical protein -
AOY77_RS01690 (363988) 363988..364269 - 282 WP_001093919.1 pyocin activator PrtN family protein -
AOY77_RS01695 (364306) 364306..364878 - 573 WP_021549910.1 3'-5' exonuclease -
AOY77_RS01700 (364878) 364878..365474 - 597 WP_021549911.1 DUF551 domain-containing protein -
AOY77_RS01705 (365478) 365478..365765 - 288 WP_021549912.1 hypothetical protein -
AOY77_RS01710 (365767) 365767..366447 - 681 WP_021549913.1 ead/Ea22-like family protein -
AOY77_RS01715 (366449) 366449..366748 - 300 WP_021549914.1 hypothetical protein -
AOY77_RS01720 (366745) 366745..367164 - 420 WP_021549915.1 hypothetical protein -
AOY77_RS01725 (367155) 367155..367691 - 537 WP_000008178.1 5'-deoxynucleotidase -
AOY77_RS01730 (367820) 367820..368644 - 825 WP_201472277.1 YfdQ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 358901..416475 57574


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(6-116)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T103555 WP_014640052.1 NZ_CP028751:363341-363727 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

>T103555 NZ_CP028751:363341-363727 [Escherichia coli]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTCTTGAATTCTGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCTGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATCTCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin


Download         Length: 170 a.a.        Molecular weight: 19576.29 Da        Isoelectric Point: 5.3338

>AT103555 WP_001339382.1 NZ_CP028751:362802-363311 [Escherichia coli]
MAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHNVSLRSDPREMDAD
EVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Download         Length: 510 bp

>AT103555 NZ_CP028751:362802-363311 [Escherichia coli]
ATGGCATATCTGAAATTGATGAAGCTGCTCTATCTGTCTAACCGCCAGTCGATTTTGAAGCATGGCAGGATGATCGGCGA
AGATAGCCTTTACTCTATGAAATTTGGACCAGTCATGTCGAATACGCTGAACTTGATTCGCGGTAAGGCTGAAGGCATTG
GTGACTACTGGTACAACTTGATAGAGACGAACGGGCATAATGTATCGTTGCGTTCAGATCCGAGGGAAATGGATGCAGAC
GAGGTCTTTGATGAATTGAGTCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCGGTATGGGCATATGAACCGATT
TGATCTCGCAAATATGACGCATTTAGAAAGCGTTTGTCCAGAGTGGCACGATCCTGGCAACTCTCGTAAGCCTATAGACC
TGAAAGAAATGCTGATCAGTGAGGGTAAAAGCGAGGATGAGGCTAATCGCATAATTGGCAAAATGGAAGAATCTCAGAAA
CTTAAGGAATTTTCTTTGCAATTATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References