Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yafW-ykfI/CbtA-CbeA |
| Location | 3651376..3652055 | Replicon | chromosome |
| Accession | NZ_CP028746 | ||
| Organism | Escherichia coli strain A29 | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | - |
| Locus tag | AOY82_RS17665 | Protein ID | WP_201479655.1 |
| Coordinates | 3651714..3652055 (+) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yafW | Uniprot ID | S1EWR7 |
| Locus tag | AOY82_RS17660 | Protein ID | WP_000070396.1 |
| Coordinates | 3651376..3651693 (+) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AOY82_RS17615 (3646812) | 3646812..3647633 | + | 822 | WP_000197387.1 | DUF932 domain-containing protein | - |
| AOY82_RS17620 (3647851) | 3647851..3648553 | + | 703 | Protein_3461 | WYL domain-containing protein | - |
| AOY82_RS17625 (3648594) | 3648594..3648830 | + | 237 | WP_001144031.1 | protein YpjK | - |
| AOY82_RS17630 (3648830) | 3648830..3649273 | + | 444 | WP_000649865.1 | hypothetical protein | - |
| AOY82_RS17635 (3649296) | 3649296..3649763 | + | 468 | WP_001385283.1 | protein YkfB | - |
| AOY82_RS17640 (3649840) | 3649840..3650079 | + | 240 | WP_000194654.1 | DUF905 family protein | - |
| AOY82_RS17645 (3650177) | 3650177..3650635 | + | 459 | WP_053275267.1 | antirestriction protein | - |
| AOY82_RS17650 (3650651) | 3650651..3651127 | + | 477 | WP_000811693.1 | RadC family protein | - |
| AOY82_RS17655 (3651136) | 3651136..3651357 | + | 222 | WP_000691994.1 | DUF987 domain-containing protein | - |
| AOY82_RS17660 (3651376) | 3651376..3651693 | + | 318 | WP_000070396.1 | type IV toxin-antitoxin system antitoxin YafW | Antitoxin |
| AOY82_RS17665 (3651714) | 3651714..3652055 | + | 342 | WP_201479655.1 | type IV toxin-antitoxin system toxin YkfI | Toxin |
| AOY82_RS17670 (3652654) | 3652654..3653013 | + | 360 | WP_001405000.1 | hypothetical protein | - |
| AOY82_RS17675 (3653006) | 3653006..3653548 | - | 543 | WP_000284450.1 | plasmid pRiA4b ORF-3 family protein | - |
| AOY82_RS17680 (3653669) | 3653669..3653854 | - | 186 | WP_000188903.1 | hypothetical protein | - |
| AOY82_RS17685 (3654152) | 3654152..3654433 | - | 282 | WP_000617443.1 | PerC family transcriptional regulator | - |
| AOY82_RS17690 (3655050) | 3655050..3656006 | + | 957 | WP_001528727.1 | hypothetical protein | - |
| AOY82_RS17695 (3656019) | 3656019..3656456 | + | 438 | WP_000098670.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3646812..3670691 | 23879 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12892.01 Da Isoelectric Point: 10.2276
>T103457 WP_201479655.1 NZ_CP028746:3651714-3652055 [Escherichia coli]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYKLVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYKLVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR
Download Length: 342 bp
>T103457 NZ_CP028746:3651714-3652055 [Escherichia coli]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACAAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACAAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11982.62 Da Isoelectric Point: 7.0270
>AT103457 WP_000070396.1 NZ_CP028746:3651376-3651693 [Escherichia coli]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR
Download Length: 318 bp
>AT103457 NZ_CP028746:3651376-3651693 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|