Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2928637..2929115 Replicon chromosome
Accession NZ_CP028744
Organism Escherichia coli strain A31

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A7D8WGY6
Locus tag AOY84_RS14245 Protein ID WP_000936798.1
Coordinates 2928828..2929115 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID D8A5B4
Locus tag AOY84_RS14240 Protein ID WP_000100899.1
Coordinates 2928637..2928828 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY84_RS14195 (2924121) 2924121..2924276 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
AOY84_RS14200 (2924568) 2924568..2925200 - 633 WP_240754870.1 hypothetical protein -
AOY84_RS14205 (2925298) 2925298..2925654 - 357 WP_240754871.1 hypothetical protein -
AOY84_RS14210 (2925656) 2925656..2925841 - 186 Protein_2775 hypothetical protein -
AOY84_RS14215 (2925983) 2925983..2926390 - 408 WP_240754872.1 DUF977 family protein -
AOY84_RS14220 (2926431) 2926431..2927393 - 963 WP_240754873.1 helix-turn-helix domain-containing protein -
AOY84_RS14225 (2927417) 2927417..2927842 - 426 WP_158130652.1 toxin YdaT family protein -
AOY84_RS14230 (2927826) 2927826..2928098 - 273 WP_097330580.1 YdaS family helix-turn-helix protein -
AOY84_RS14235 (2928208) 2928208..2928609 + 402 WP_001329851.1 helix-turn-helix domain-containing protein -
AOY84_RS14240 (2928637) 2928637..2928828 + 192 WP_000100899.1 hypothetical protein Antitoxin
AOY84_RS14245 (2928828) 2928828..2929115 + 288 WP_000936798.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AOY84_RS14250 (2929389) 2929389..2929544 + 156 WP_000379575.1 DUF1391 family protein -
AOY84_RS23385 (2929546) 2929546..2929674 + 129 WP_256127124.1 protein YdfB -
AOY84_RS14255 (2929704) 2929704..2929922 + 219 WP_001171942.1 protein YdfC -
AOY84_RS14260 (2929926) 2929926..2930090 - 165 WP_001331716.1 hypothetical protein -
AOY84_RS14265 (2930490) 2930490..2930678 + 189 WP_000854558.1 cell division inhibition protein DicB -
AOY84_RS14270 (2930675) 2930675..2930866 + 192 WP_001070255.1 DUF1482 family protein -
AOY84_RS14275 (2930960) 2930960..2933401 + 2442 WP_039022660.1 exonuclease -
AOY84_RS14280 (2933460) 2933460..2933663 + 204 WP_000096346.1 DUF4224 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10899.83 Da        Isoelectric Point: 10.1360

>T103402 WP_000936798.1 NZ_CP028744:2928828-2929115 [Escherichia coli]
MLPILWLPSARDDLRQIVAYIAKENIPAARRLKIRIETSVLALSEHPYLYPPSDRVSGLREIVVHPNYIVLYRVAASSIE
IANIVHARRQFPFPI

Download         Length: 288 bp

>T103402 NZ_CP028744:2928828-2929115 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCATCTGCTCGCGATGATTTGCGTCAGATCGTAGCCTATATTGCCAAGGAAAATATTCC
TGCAGCACGCAGGCTAAAAATACGTATTGAAACGTCTGTTTTAGCCCTCTCCGAGCATCCATATCTATATCCGCCAAGTG
ATCGAGTATCCGGTTTGCGGGAAATTGTGGTTCACCCTAATTATATCGTTTTATACCGAGTAGCAGCTTCAAGCATTGAA
ATTGCAAATATTGTGCATGCCCGCCGACAATTTCCCTTCCCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7035.80 Da        Isoelectric Point: 4.0270

>AT103402 WP_000100899.1 NZ_CP028744:2928637-2928828 [Escherichia coli]
MSTALSPIVSEFETTEQENSYNEWLRAKVASSLADPRPSIPHDEVMAEMENLIAQIAVTNRSE

Download         Length: 192 bp

>AT103402 NZ_CP028744:2928637-2928828 [Escherichia coli]
ATGAGTACAGCCCTTTCTCCGATAGTTTCAGAGTTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCGC
TAAAGTGGCGTCAAGCCTTGCAGACCCTCGCCCCTCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAGGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D8WGY6

Antitoxin

Source ID Structure
AlphaFold DB A0A161RC07

References