Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 658720..659423 Replicon chromosome
Accession NZ_CP028742
Organism Escherichia coli strain A33

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag AOY86_RS03060 Protein ID WP_240768569.1
Coordinates 659082..659423 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag AOY86_RS03055 Protein ID WP_000842922.1
Coordinates 658720..659061 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY86_RS03015 (654272) 654272..654976 + 705 WP_000083852.1 WYL domain-containing protein -
AOY86_RS03020 (654976) 654976..655545 + 570 WP_000735596.1 hypothetical protein -
AOY86_RS03025 (655560) 655560..656012 + 453 WP_000737910.1 hypothetical protein -
AOY86_RS03030 (656009) 656009..656458 + 450 WP_000976949.1 IrmA family protein -
AOY86_RS03035 (656530) 656530..656760 + 231 WP_000829403.1 DUF905 domain-containing protein -
AOY86_RS03040 (656859) 656859..657680 + 822 WP_001234403.1 DUF932 domain-containing protein -
AOY86_RS03045 (657711) 657711..658154 + 444 WP_000354463.1 antirestriction protein -
AOY86_RS03050 (658167) 658167..658709 + 543 WP_001090454.1 DNA repair protein RadC -
AOY86_RS03055 (658720) 658720..659061 + 342 WP_000842922.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AOY86_RS03060 (659082) 659082..659423 + 342 WP_240768569.1 TA system toxin CbtA family protein Toxin
AOY86_RS03065 (659681) 659681..660688 + 1008 WP_000528273.1 restriction endonuclease -
AOY86_RS03070 (661095) 661095..664211 - 3117 WP_000149658.1 HsdR family type I site-specific deoxyribonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(13-111)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12760.68 Da        Isoelectric Point: 7.2767

>T103326 WP_240768569.1 NZ_CP028742:659082-659423 [Escherichia coli]
MKTLPATNPQAATLCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
DWQEHSQYLRAVDILRARQATGLLKINRISAAR

Download         Length: 342 bp

>T103326 NZ_CP028742:659082-659423 [Escherichia coli]
ATGAAAACTCTACCTGCAACAAATCCGCAGGCGGCGACGCTATGTCTGTCGCCCGTGGCAGTTTGGCAAATGCTGCTTAC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCTGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTGCGTATTGATCGCAGGGGATTT
GACTGGCAAGAACACTCCCAATATCTGCGGGCAGTCGATATTCTGCGGGCGCGACAAGCAACTGGTTTATTGAAAATAAA
TCGTATTAGCGCGGCACGGTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12877.61 Da        Isoelectric Point: 6.7389

>AT103326 WP_000842922.1 NZ_CP028742:658720-659061 [Escherichia coli]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGKFINAEYLKLDEIFPHFISQMESMLITGEMNPRH
AHCVTLYHNGFTCEADTLGSCGYVYIAVYPTHR

Download         Length: 342 bp

>AT103326 NZ_CP028742:658720-659061 [Escherichia coli]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTCAAGTGGGGTCTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGACTGCACTATCTGGCTGACCGGGCCAGCATTACCGGTAAATTCATTAACGCAGAATATT
TGAAGTTGGATGAAATATTCCCGCATTTTATCAGCCAGATGGAATCGATGCTGATCACTGGTGAAATGAATCCTCGCCAT
GCCCACTGTGTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTATGTATACATCGC
CGTTTACCCCACTCATCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References